Rodent models of experimental autoimmune uveitis.
Rodent models of experimental autoimmune uveitis.
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DOI：
10.1007/978-1-60761-720-4_22
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发表时间：
2012
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影响因子：
--
通讯作者：
Caspi, Rachel R
中科院分区：
文献类型：
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作者：
Agarwal, Rajeev K;Silver, Phyllis B;Caspi, Rachel R
介绍了实验性自身免疫性葡萄膜炎(EAU)的小鼠和大鼠模型。EAU针对免疫特权视网膜抗原，是人类自身免疫性葡萄膜炎的模型，也是更一般意义上的自身免疫的模型。EAU是一个特征良好、健壮且可重现的模型，易于遵循和量化。在常见的大鼠和小鼠品系中，它可以用来自视网膜自身抗原的合成肽诱导。不同的基因操作，包括人类白细胞抗原转基因小鼠株系，都能诱导EAU的发生，这使得EAU模型适合于基础机制的研究和临床相关的干预。
The model of experimental autoimmune uveitis (EAU) in mice and in rats is described. EAU targets immunologically privileged retinal antigens and serves as a model of autoimmune uveitis in humans as well as a model for autoimmunity in a more general sense. EAU is a well-characterized, robust, and reproducible model that is easily followed and quantitated. It is inducible with synthetic peptides derived from retinal autoantigens in commonly available strains of rats and mice. The ability to induce EAU in various gene-manipulated, including HLA-transgenic, mouse strains makes the EAU model suitable for the study of basic mechanisms as well as in clinically relevant interventions.