Microvessel density and expression of vascular endothelial growth factor, basic fibroblast growth factor, and platelet-derived endothelial growth factor in oral squamous cell carcinomas
Microvessel density and expression of vascular endothelial growth factor, basic fibroblast growth factor, and platelet-derived endothelial growth factor in oral squamous cell carcinomas
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DOI：
10.1016/j.ijom.2004.10.016
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发表时间：
2005-07-01
影响因子：
2.4
通讯作者：
Hamakawa, H
中科院分区：
文献类型：
--
作者：
Li, C;Shintani, S;Hamakawa, H
血管生成，即毛细血管的生长，在恶性组织的代谢功能中起重要作用。肿瘤生长和恶性转化被认为是由不受控制的血管生成主导的。为了了解与恶性组织相关的血管生成增加的机制，我们用化学发光法检测了口腔癌中微血管密度（MVD）和血管内皮生长因子（VEGF）、碱性成纤维细胞生长因子（bFGF）和血小板源性内皮生长因子（PDGF）的表达。微血管密度在正常口腔粘膜和上皮异型增生之间没有显著差异，但在肿瘤组织中显著增加。血管生成因子的表达在正常口腔粘膜中没有发现，但在口腔鳞癌组织中随着血管的增加而增加。肿瘤组织中血管生成因子的表达与MVD相关。MVD与肿瘤的T分期、分化程度、浸润深度有关。VEGF表达与肿瘤分化程度、浸润深度有关。提示VEGF在口腔鳞癌血管生成中起重要作用。
Angiogenesis, the growth of capillary vessels, plays an important role in the metabolic functions of malignant tissues. Tumor growth and malignant transformation are considered to be dominated by uncontrolled angiogenesis. To understand the mechanism of increased vascularity associated with malignant tissues, we immunohistochemically evaluated microvessel density (MVD) and the expression of vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF), and platelet-derived endothelial growth factor (PDGF) in oral cancers. Microvessel density did not differ significantly between normal oral mucosa and epithelial dysplasia, but was significantly increased in tumor tissues. Expression of angiogenic factors was not found in normal oral mucosa, but increased in association with increasing vascularity in OSCC tissue. In tumor tissue, angiogenic factor expression correlated with MVD. MVD in OSCC was related to T stage, tumor-differentiation, and stage of invasion. VEGF expression also correlated with tumor differentiation and the stage of invasion. These findings suggest that VEGF might play an important role in tumor angiogenesis of OSCC.