A novel anti-tumor agent, polyoxomolybdate induces apoptotic cell death in AsPC-1 human pancreatic cancer cells
A novel anti-tumor agent, polyoxomolybdate induces apoptotic cell death in AsPC-1 human pancreatic cancer cells
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DOI：
10.1016/j.biopha.2004.11.008
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发表时间：
2005-06-01
影响因子：
7.5
通讯作者：
Eriguchi, M
中科院分区：
文献类型：
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作者：
Ogata, A;Mitsui, S;Eriguchi, M
在研究多金属氧酸盐作为金属氧化物离散簇阴离子的医学应用过程中，人们对抗肿瘤多钼酸盐进行了研究。[NH_3 Pi]（6）[Mo_7 O_（24）]中心点~ 3 H_（2）O（PM-8）是一种具有显著抗肿瘤活性的钼酸盐。PM-8抑制人胰腺细胞（AsPC-1）的细胞生长，这取决于剂量。Hoechst染色、TUNEL染色及流式细胞术分析DNA梯状条带形成及DNA断裂。PM-8处理24、48和72 h后凋亡细胞的比例分别为29%、35%和57%，这表明PM-8的抗肿瘤活性是通过激活凋亡途径的结果。多氧钼酸盐提供了有前途的新型抗肿瘤剂，特别是用于治疗难以治疗的癌症。All rights reserved.
Anti-tumoral polyoxomolybdates have been investigated in the course of study of the medical application of polyoxometalates as discrete cluster anions of metal oxides. [NH3Pi](6)[Mo7O24]center dot 3H(2)O (PM-8) has been recognized as one of significantly anti-tumoral polyoxomolybdates. PM-8 inhibited the cell growth of human pancreatic cells (AsPC-1) depending on the dose. DNA ladder formation and DNA fragmentation were observed by Hoechst and TUNEL staining and flowcytometry analysis. The ratio of apoptotic cells were 29%, 35%, and 57% with treatment of PM-8 after 24, 48, and 72 h, respectively, which suggested that the anti-tumor activity of PM-8 results from the activation of the apoptotic pathway. Polyoxomolybdates provide promising, novel anti-tumor agent, especially for the treatment of cancers that are difficult to treat. (c) 2005 Elsevier SAS. All rights reserved.