INCREASED EXERCISE VENTILATION IN PATIENTS WITH CHRONIC HEART-FAILURE - INTACT VENTILATORY CONTROL DESPITE HEMODYNAMIC AND PULMONARY ABNORMALITIES
INCREASED EXERCISE VENTILATION IN PATIENTS WITH CHRONIC HEART-FAILURE - INTACT VENTILATORY CONTROL DESPITE HEMODYNAMIC AND PULMONARY ABNORMALITIES
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DOI：
10.1161/01.cir.77.3.552
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发表时间：
1988-03-01
期刊：
影响因子：
37.8
通讯作者：
COBB, FR
中科院分区：
文献类型：
--
作者：
SULLIVAN, MJ;HIGGINBOTHAM, MB;COBB, FR
This study was designed to determine the pathophysiologic basis of increased exercise ventilation in the presence of chronic heart failure. Sixty-four ambulatory patients with chronic heart failure and 38 age-matched normal control subjects performed exercise according to identical staged, symptom-limited bicycle exercise protocols with measurement of hemodynamic, ventilatory, and metabolic responses. Compared with normal subjects, ventilation and the ratio of ventilation to CO2 production (Ve/VCO2), and pulmonary capilary wedge pressure were elevated in patients at rest and during exercise. The ratio of pulmonary dead space to tidal volume (Vd/Vt) also was elevated in the heart failure group at rest and during exercise and was closely related to Ve/VCO2 (all r>.72, p
