Antibacterial alkaloids from Zanthoxylum rhoifolium
Antibacterial alkaloids from Zanthoxylum rhoifolium
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DOI：
10.1055/s-2003-38882
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发表时间：
2003-04-01
期刊：
影响因子：
2.7
通讯作者：
Morel, AF
中科院分区：
文献类型：
--
作者：
Gonzaga, WDA;Weber, AD;Morel, AF
从花椒树皮中分离得到2个新的二氢二氢苯并菲类生物碱6-甲氧基[1，3]dioxolo[4‘，5’：4，5]benzo[c][1，3]dioxolo[4，5-j]phenanthridine(1)和2，3，13-trimethoxy-5，11a-dihydro[1，3]dioxolo[4‘，5’：4，5]benzo[c]phenanthridine(2)，以及4个已知的苯并菲生物碱：6-丙酮基二氢白藜碱(3){=8-丙酮基二氢罗尼替丁}，6-丙酮基二氢阿维碱(4){=8-丙酮基二氢阿维辛}，6-丙酮基二氢白屈菜碱(5)和黄氧碱(6)。这些化合物的结构主要通过波谱方法确定，包括一维和二维核磁共振波谱。对于生物碱1和2，我们建议将其命名为罗汉果碱A和B。植物粗提物和生物碱3、4和6对革兰氏(+/-)菌有抑制作用，而新生物碱1和2则没有活性。
Two new dihydrobenzophenanthridine-type alkaloids, 6-methoxy [1,3]dioxolo[4',5':4,5]benzo[c][1,3]dioxolo[4,5-j]phenanthridine (1) and 2,3,13-trimethoxy-5,11a-dihydro[1,3]dioxolo[4',5':4,5]benzo[c]phenanthridine (2) were isolated from the stern bark of Zanthoxylum rhoifolium, together with four other previously known benzophenanthridine alkaloids, 6-acetonyldihydronitidine (3) { = 8-acetonyldihydronitidine}, 6-acetonyldihydroavicine (4) { = 8-acetonyldihydroavicine}, 6-acetonyldihydrochelerythrine (5) and xanthoxyline (6). The structures were elucidated mainly by spectroscopic methods, including 1 D and 2D NMR spectroscopy. For alkaloids 1 and 2 we propose the trivial names rhoifolines A and B. The crude plant extracts and the alkaloids 3,4 and 6 showed activity against Gram (+/-) bacteria, while the new alkaloids 1 and 2 were inactive.