The immunomodulator FTY720 is phosphorylated and released from platelets
The immunomodulator FTY720 is phosphorylated and released from platelets
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DOI：
10.1016/j.ejphar.2007.04.053
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发表时间：
2007-07-30
影响因子：
5
通讯作者：
Kihara, Akio
中科院分区：
文献类型：
--
作者：
Anada, Yoshihiro;Igarashi, Yasuyuki;Kihara, Akio
新型免疫调节剂FTY 720导致外周血淋巴细胞在淋巴组织中积聚。在体内，FTY 720被磷酸化为FTY 720-P，其结合1-磷酸鞘氨醇受体SlP。到目前为止，尚不清楚FTY720-P的生产地点。我们证明血小板有效地将FTY720转化为FTY720-P并将其释放到细胞外空间。这种释放主要不依赖于血小板活化，但在凝血酶刺激时略有增加。这些结果表明，血小板是血浆FTY 720-P的主要来源，FTY 720-P的释放是由两种不同的转运蛋白介导的。(C)2007 Elsevier B.V.保留所有权利。
The novel immunomodulator FTY720 causes lymphocytes from peripheral blood to accumulate in lymphoid tissues. In vivo, FTY720 is phosphorylated to FTY720-P, which binds to the sphingosine 1-phosphate receptor SIP,. So far, it has been unclear where FTY720-P is produced. We demonstrate that platelets efficiently convert FTY720 to FTY720-P and release it into the extracellular space. This release is mostly independent of platelet activation, but is slightly increased upon thrombin stimulation. These results suggest that platelets are a major source of plasma FTY720-P, and that FTY720-P release is mediated by two different transporters. (C) 2007 Elsevier B.V. All rights reserved.