A Method to the Madness: Producing the Neonatal Ventral Hippocampal Lesion Rat Model of Schizophrenia
A Method to the Madness: Producing the Neonatal Ventral Hippocampal Lesion Rat Model of Schizophrenia
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DOI：
10.1007/978-1-61779-157-4_1
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发表时间：
2011-01-01
期刊：
影响因子：
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通讯作者：
Lipska, Barbara K.
中科院分区：
文献类型：
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作者：
Chambers, R. Andrew;Lipska, Barbara K.
精神分裂症的新生儿腹侧海马病变 (NVHL) 大鼠模型已显示出作为一个研究平台的广泛启发性实用性，涵盖了这种影响 1% 人类的破坏性神经精神疾病的许多行为、神经生物学和发育方面。本章对用于生成和验证大鼠 NVHL 模型的材料和方法进行了必要的描述，该模型在帮助我们了解精神分裂症、共病障碍及其神经发育动力学方面仍然具有巨大的潜力。这里描述的许多方法可以进行修改或调整，以产生其他类型的行为障碍神经发育模型。
The neonatal ventral hippocampal lesion (NVHL) rat model of schizophrenia has demonstrated broad heuristic utility as an investigative platform encompassing many of the behavioral, neurobiological, and developmental aspects of this devastating neuropsychiatric illness affecting 1% of all human beings. This chapter serves as an essential description of materials and methods for generating and verifying the NVHL model in rats, which continues to hold significant potential in helping us understand schizophrenia, comorbid disorders, and their neurodevelopmental dynamics. Many of the approaches described here can be modified or adapted for producing other types of neurodevelopmental models of behavioral disorders.