Nuclear receptors as targets for drug development: the role of nuclear receptors during neural stem cell proliferation and differentiation.
Nuclear receptors as targets for drug development: the role of nuclear receptors during neural stem cell proliferation and differentiation.
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DOI：
10.1254/jphs.fmj04008x3
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发表时间：
2005
影响因子：
3.5
通讯作者：
K. Katayama;K. Wada;A. Nakajima;Y. Kamisaki;T. Mayumi
中科院分区：
文献类型：
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作者：
K. Katayama;K. Wada;A. Nakajima;Y. Kamisaki;T. Mayumi
干细胞（例如神经干细胞和造血干细胞）的命运取决于严格调控的信号事件，包括核受体的激活，从而导致随后的基因诱导。最近，我们证明PPARγ是一种配体激活的核受体，在调节小鼠神经干细胞（NSC）的增殖和分化中发挥重要作用。与野生型小鼠相比，杂合 PPARgamma 缺陷小鼠制备的 NSC 生长速度较慢，这在通过慢病毒载体介导的 RNA 干扰方法产生的 PPARgamma 敲低 NSC 中也得到了证明。这些研究对于了解中枢神经系统功能和开发神经退行性疾病的治疗方法具有重要意义。在这篇综述中，我们将讨论干细胞生物学的最新发现，特别是针对 NSC 核受体的研究，包括我们目前的研究。
The fate of stem cells, such as neural stem cells and hematopoietic stem cells, depends on strictly regulated signaling events including activation of nuclear receptors, resulting in subsequent gene induction. Recently, we demonstrated that PPARgamma, a ligand-activated nuclear receptor, plays an important role in regulating the proliferation and differentiation of murine neural stem cell (NSC). NSC prepared from heterozygous PPARgamma-deficient mouse exhibited a slower growth rate compared with that of wild-type mouse, which was also demonstrated in PPARgamma-knockdown NSC that was generated by the lentiviral-vector-mediated RNA interference approach. These studies have important implications for understanding central nervous system functions and developing a therapy for neurodegenerative disorders. In this review, recent findings on stem cell biology, especially focusing on nuclear receptors in NSCs, including our current study, will be discussed.