Magnetic field-driven induction of ZENK in the trigeminal system of pigeons (Columba livia)
Magnetic field-driven induction of ZENK in the trigeminal system of pigeons (Columba livia)
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DOI：
10.1098/rsif.2014.0777
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发表时间：
2014-11-06
影响因子：
3.9
通讯作者：
Mouritsen, Henrik
中科院分区：
文献类型：
--
作者：
Lefeldt, Nele;Heyers, Dominik;Mouritsen, Henrik
磁感应仍然是感觉生物学中为数不多的未解之谜之一。上喙由三叉神经的眼支(V1)支配，被认为含有基于铁磁结构的磁传感器。最近，它在鸽子中的存在受到了严重挑战，因为有研究表明，以前描述的铁积累是巨噬细胞，而不是磁敏神经末梢。这提出了一个根本的问题，即V1是否参与鸽子的磁感应。我们将鸽子暴露在不断变化的磁场(CMF)中，或者暴露在不提供磁信息的零磁场中，或者暴露在V1双侧切断后的CMF条件下。利用即刻早期基因作为神经元反应性的标志，我们报道了接受V1输入的鸽子三叉神经脑干核团在CMF条件下被激活，如果磁刺激被移除或V1被切断，这种神经元激活就消失了。我们的数据表明，鸽子的三叉神经系统参与了磁场信息的处理，V1将这些信息从目前未知的V1相关的磁传感器传递到大脑。
Magnetoreception remains one of the few unsolved mysteries in sensory biology. The upper beak, which is innervated by the ophthalmic branch of the trigeminal nerve (V1), has been suggested to contain magnetic sensors based on ferromagnetic structures. Recently, its existence in pigeons has been seriously challenged by studies suggesting that the previously described iron-accumulations are macrophages, not magnetosensitive nerve endings. This raised the fundamental question of whether V1 is involved in magneto-reception in pigeons at all. We exposed pigeons to either a constantly changing magnetic field (CMF), to a zero magnetic field providing no magnetic information, or to CMF conditions after V1 was cut bilaterally. Using immediate early genes as a marker of neuronal responsiveness, we report that the trigeminal brainstem nuclei of pigeons, which receive V1 input, are activated under CMF conditions and that this neuronal activation disappears if the magnetic stimuli are removed or if V1 is cut. Our data suggest that the trigeminal system in pigeons is involved in processing magnetic field information and that V1 transmits this information from currently unknown, V1-associated magnetosensors to the brain.