Posttraumatic stress disorder and cancer risk: a nationwide cohort study.
Posttraumatic stress disorder and cancer risk: a nationwide cohort study.
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DOI：
10.1007/s10654-015-0032-7
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发表时间：
2015-07
影响因子：
13.6
通讯作者：
Sørensen HT
中科院分区：
文献类型：
--
作者：
Gradus JL;Farkas DK;Svensson E;Ehrenstein V;Lash TL;Milstein A;Adler N;Sørensen HT
压力和癌症发病率之间的关系已经研究了七十多年。尽管有合理的生物学机制和实验室研究的证据，但临床研究的结果相互矛盾。这项研究的目的是检查PTSD和各种癌症结果之间的关联。这项全国性的队列研究包括1995年至2011年丹麦所有丹麦出生的居民。暴露为PTSD诊断（n = 4，131）。主要结局是癌症诊断，包括：1）所有恶性肿瘤; 2）血液恶性肿瘤; 3）免疫相关癌症; 4）吸烟和酒精相关癌症; 5）所有其他部位的癌症。计算标准化发病率比（SIR）。无论是总体（所有癌症的SIR = 1.0，95%置信区间（CI）= 0.88，1.2）还是按性别、年龄、药物滥用史和自创伤后应激障碍诊断以来的时间分层的分析，都发现创伤后应激障碍与几乎所有癌症诊断之间无关联。这项研究是迄今为止对PTSD作为许多癌症类型的预测因子的最全面的检查。我们的数据显示，在这个全国性的队列中，没有证据表明PTSD和癌症之间存在关联。
The association between stress and cancer incidence has been studied for more than seven decades. Despite plausible biological mechanisms and evidence from laboratory studies, findings from clinical research are conflicting. The objective of this study was to examine the association between PTSD and various cancer outcomes. This nation-wide cohort study included all Danish-born residents of Denmark from 1995 – 2011. The exposure was PTSD diagnoses (n = 4,131). The main outcomes were cancer diagnoses including: 1) all malignant neoplasms; 2) hematologic malignancies; 3) immune-related cancers; 4) smoking- and alcohol-related cancers; 5) cancers at all other sites. Standardized incidence ratios (SIR) were calculated. Null associations were found between PTSD and nearly all cancer diagnoses examined, both overall (SIR for all cancers = 1.0, 95% confidence interval (CI) = 0.88, 1.2) and in analyses stratified by gender, age, substance abuse history and time since PTSD diagnosis. This study is the most comprehensive examination to date of PTSD as a predictor of many cancer types. Our data show no evidence of an association between PTSD and cancer in this nationwide cohort.