Dosimetry and preliminary acute toxicity in the first 100 men treated for prostate cancer on a randomized hypofractionation dose escalation trial
Dosimetry and preliminary acute toxicity in the first 100 men treated for prostate cancer on a randomized hypofractionation dose escalation trial
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DOI：
10.1016/j.ijrobp.2005.07.970
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发表时间：
2006-02-01
影响因子：
7
通讯作者：
Price, RA
中科院分区：
文献类型：
--
作者：
Pollack, A;Hanlon, AL;Price, RA
目的：前列腺癌的α/β比值假定在1和3之间，从而产生了低分割可能具有治疗优势的假设。在第一个100名男子参加了一个随机trial.Patients和方法：试验比较了76戈伊在38个分数（臂1）70.2戈伊在26个分数（臂II）使用调强放疗的剂量测定和急性毒性。I组和11组的计划靶体积（PTV）边缘向后分别为5 mm和3 mm，所有其他尺寸分别为8 mm和7 mm。结果：I组和II组的平均PTV剂量分别为81.1和73.8戈伊。总体最大急性胃肠道（GI）或泌尿生殖系统（GU）毒性无差异。然而，在第2、3和4周期间，第II组GI毒性轻微但显著增加。在多变量分析中，只有联合直肠DVH参数的V65戈伊/V50戈伊是显着的胃肠道毒性和膀胱容量为GU toxicity.Conclusion：Hypofractionation在2.7戈伊每部分到70.2戈伊急性使用所描述的规划条件耐受性良好。(C)2006年爱思唯尔公司
Purpose: The alpha/beta ratio for prostate cancer is postulated to be between 1 and 3, giving rise to the hypothesis that there may be a therapeutic advantage to hypofractionation. The dosimetry and acute toxicity are described in the first 100 men enrolled in a randomized trial.Patients and Methods: The trial compares 76 Gy in 38 fractions (Arm 1) to 70.2 Gy in 26 fractions (Arm II) using intensity modulated radiotherapy. The planning target volume (PTV) margins in Arms I and 11 were 5 mm and 3 mm posteriorly and 8 mm and 7 mm in all other dimensions. The PTV D95% was at least the prescription dose.Results: The mean PTV doses for Arms I and II were 81.1 and 73.8 Gy. There were no differences in overall maximum acute gastrointestinal (GI) or genitourinary (GU) toxicity acutely. However, there was a slight but significant increase in Arm II GI toxicity during Weeks 2, 3, and 4. In multivariate analyses, only the combined rectal DVH parameter of V65 Gy/V50 Gy was significant for GI toxicity and the bladder volume for GU toxicity.Conclusion: Hypofractionation at 2.7 Gy per fraction to 70.2 Gy was well tolerated acutely using the planning conditions described. (C) 2006 Elsevier Inc.