Restoration of disturbed intracortical motor inhibition and facillitation in attention deficit hyperactivity disorder children by methylphenidate
Restoration of disturbed intracortical motor inhibition and facillitation in attention deficit hyperactivity disorder children by methylphenidate
复制标题
DOI：
10.1016/j.biopsych.2007.05.010
复制
发表时间：
2007-11-01
影响因子：
10.6
通讯作者：
Wolters, Alexander
中科院分区：
文献类型：
--
作者：
Buchmann, Johannes;Gierow, Wolfgang;Wolters, Alexander
背景资料：先前使用经颅磁刺激（TMS）的研究表明，ADHD儿童的神经抑制运动回路受到干扰。方法：对18名ADHD儿童采用TMS配对脉冲法（ISI为3、13、50、100、200、300 msec），观察哌甲酯（MPH）对ADHD儿童抑制性和易化性运动回路的影响。并接受MPH治疗结果：方差分析（ANOVA）揭示了一个显着的三因素相互作用“组X振幅X ISI”，p = 0.001。随后的双因子方差分析和t检验显示，运动诱发电位（MEP）振幅的组特异性差异为3和100毫秒的抑制性ISI，以及13和50毫秒的易化性ISI。与对照组相比，可以显示MPH对这些参数的调整。在MPH，一个显着的双变量之间的相关性被发现的Conners评分减少和平均MEP振幅变化仅为抑制性ISIs Q和100 msec）。结论：在ADHD儿童，MPH调制紊乱的易化和抑制性运动电路，后者是与临床改善。
Background: Previous investigations using transcranial magnetic stimulation (TMS) have shown that neural inhibitory motor circuits are disturbed in ADHD children. We sought to investigate the influence of methylphenidate (MPH) on inhibitory and facilitatory motor circuits of ADHD children with TMS paired pulse protocols using surplus long interval inter-stimulus intervals (ISI) not investigated so far.Methods: Motorcortical modulation was tested with TMS paired pulse protocols employing ISI of 3, 13, 50,100, 200, and 300 msec in 18 ADHD children before! and on treatment with MPH. Clinical improvement by MPH was measured by the Conners score.Results: Analysis of variance (ANOVA) revealed a significant three-way interaction "Group X Amplitude X ISI," p =.001. Subsequent two-factorial ANOVAs and t-tests showed group specific differences of motor evoked potential (MEP) amplitudes for inhibitory ISIs of 3 and 100 msec, and for facilitatory ISIs of 13 and 50 msec. Compared to controls, an adjustment of these parameters by MPH could be shown. On MPH, a significant bivariate correlation was found between the Conners score reduction and averaged MEP amplitude changes only for inhibitory ISIs Q and 100 msec).Conclusions: In ADHD children, MPH modulates disturbed facilitatory and inhibitory motor circuits, which for the latter is associated with clinical improvement.