Genomic and phenotypic heterogeneity in prostate cancer.
Genomic and phenotypic heterogeneity in prostate cancer.
复制标题
前列腺癌的基因组和表型异质性。
DOI：
10.1038/s41585-020-00400-w
复制
发表时间：
2021-03
期刊：
影响因子：
--
通讯作者：
Yegnasubramanian S
中科院分区：
文献类型：
--
作者：
Haffner MC;Zwart W;Roudier MP;True LD;Nelson WG;Epstein JI;De Marzo AM;Nelson PS;Yegnasubramanian S
从临床、形态学和分子生物学角度来看，前列腺癌是一种异质性疾病。原发性前列腺癌通常是多灶性的，具有地形学和形态学上不同的肿瘤病灶。测序研究表明，个别肿瘤病灶可以出现克隆不同的病变，没有共享的驱动基因的改变。这一发现表明，多个基因组和表型不同的原发性前列腺癌可以存在于一个单独的患者。致死性转移性前列腺癌似乎起源于原发肿瘤中的单个克隆，但在基因组、表观遗传和表型水平上可表现出亚克隆异质性。总的来说，这种复杂的异质性分子改变的星座构成了前列腺癌的诊断和治疗的障碍。然而，我们对肿瘤内异质性的理解和新技术的发展将使我们能够应对这些挑战，完善转化研究方法，并最终改善患者护理。
From a clinical, morphological and molecular perspective, prostate cancer is a heterogeneous disease. Primary prostate cancers are often multifocal, having topographically and morphologically distinct tumour foci. Sequencing studies have revealed that individual tumour foci can arise as clonally distinct lesions with no shared driver gene alterations. This finding demonstrates that multiple genomically and phenotypically distinct primary prostate cancers can be present in an individual patient. Lethal metastatic prostate cancer seems to arise from a single clone in the primary tumour but can exhibit subclonal heterogeneity at the genomic, epigenetic and phenotypic levels. Collectively, this complex heterogeneous constellation of molecular alterations poses obstacles for the diagnosis and treatment of prostate cancer. However, advances in our understanding of intra-tumoural heterogeneity and the development of novel technologies will allow us to navigate these challenges, refine approaches for translational research and ultimately improve patient care.
登录
查看更多内容
影响因子：
82.9
作者：
Beltran H;Prandi D;Mosquera JM;Benelli M;Puca L;Cyrta J;Marotz C;Giannopoulou E;Chakravarthi BV;Varambally S;Tomlins SA;Nanus DM;Tagawa ST;Van Allen EM;Elemento O;Sboner A;Garraway LA;Rubin MA;Demichelis F
通讯作者：
Demichelis F
影响因子：
11.2
作者：
Alexander, Joan;Kendall, Jude;Krasnitz, Alexander
通讯作者：
Krasnitz, Alexander
DOI：
10.1056/nejmoa1315815
发表时间：
2014-09-11
期刊：
The New England journal of medicine
影响因子：
--
作者：
Antonarakis ES;Lu C;Wang H;Luber B;Nakazawa M;Roeser JC;Chen Y;Mohammad TA;Chen Y;Fedor HL;Lotan TL;Zheng Q;De Marzo AM;Isaacs JT;Isaacs WB;Nadal R;Paller CJ;Denmeade SR;Carducci MA;Eisenberger MA;Luo J
通讯作者：
Luo J
影响因子：
82.9
作者：
Andor N;Graham TA;Jansen M;Xia LC;Aktipis CA;Petritsch C;Ji HP;Maley CC
通讯作者：
Maley CC
影响因子：
17.1
作者：
Aryee MJ;Liu W;Engelmann JC;Nuhn P;Gurel M;Haffner MC;Esopi D;Irizarry RA;Getzenberg RH;Nelson WG;Luo J;Xu J;Isaacs WB;Bova GS;Yegnasubramanian S
通讯作者：
Yegnasubramanian S