Bile Acids in Portal Blood of Rats Fed Different Diets and Cholestyramine
Bile Acids in Portal Blood of Rats Fed Different Diets and Cholestyramine
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饲喂不同饮食和考来烯胺的大鼠门血中的胆汁酸
DOI：
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发表时间：
1967
期刊：
影响因子：
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通讯作者：
J. Sjövall
中科院分区：
文献类型：
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作者：
T. Cronholm;J. Sjövall
用气相色谱法测定了大鼠门静脉血和肠内容物中的二羟基和三羟基胆汁酸。门静脉血清中胆酸、猪氧胆酸、β-鼠胆酸、鹅去氧胆酸和脱氧胆酸分别占胆汁酸的65%、13%、12%、5%和5%。当一个商业颗粒食品给予约65%的这些酸共轭相比，90%时，低体积半合成饮食喂养。不同胆汁酸之间的比例在小肠内容物和门静脉血清中相似。游离胆汁酸和猪去氧胆酸和脱氧胆酸的比例较高的门静脉血引流肠的远端部分。
总胆汁酸浓度约为60 μM，部分由于采样条件而存在较大差异。消胆胺，1%的饮食，没有改变的浓度或组成的胆汁酸测定。
所获得的数据不支持这样的理论，即胆固醇产生胆汁酸是通过胆汁酸通过门静脉血返回肝脏的直接反馈抑制来调节的。
Dihydroxy and trihydroxy bile acids in the portal blood and intestinal contents of rats were analyzed by a gas chromatographic method. Cholic, hyodoxycholic, β-muricholic, chenodeoxycholic and deoxycholic acids made up about 65, 13, 12, 5 and 5% respectively of the bile acids in portal serum. When a commercial pellet food was given about 65% of these acids were conjugated as compared with 90% when a low-bulk semisynthetic diet was fed. The ratios between the different bile acids were similar in small intestinal contents and portal serum. The proportion of free bile acids and of hyodeoxycholic and deoxycholic acids was higher in portal blood draining the distal part of the intestine.
The total bile acid concentration was about 60 μM with large variations partly due to sampling conditions. Cholestyramine, 1% in the diet, did not change the concentration or composition of the bile acids determined.
The data obtained do not support the theory that the production of bile acids from cholesterol is regulated through a direct feedback inhibition by the bile acids returned to the liver via the portal blood.