HELIX SIGNALS IN PROTEINS
HELIX SIGNALS IN PROTEINS
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DOI：
10.1126/science.2837824
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发表时间：
1988-06-17
期刊：
影响因子：
56.9
通讯作者：
ROSE, GD
中科院分区：
文献类型：
--
作者：
PRESTA, LG;ROSE, GD
α螺旋，首先由Pauling及其同事提出，是蛋白质结构的标志，许多努力都是为了了解哪些序列可以形成螺旋。这里介绍的螺旋假说为这个问题提供了一个初步的答案。该假说指出，螺旋形成的必要条件是存在螺旋末端侧翼的残基，其侧链可以与初始的四螺旋> N. sbd. H基团和最终的四螺旋> C.sbd.O基团形成氢键;否则这八个基团将缺乏螺旋内配偶体。这个简单的假设意味着存在一个立体化学密码，其中某些序列具有氢键能力作为螺旋边界，从而使螺旋能够自主形成。蛋白质的三维结构是遗传密码的结果，但与结构相关的序列仍然未知。随后的分析支持α的立体化学编码是一种立体化学编码的观点。螺旋在其边界残基。
The .alpha. helix, first proposed by Pauling and co-workers, is a hallmark of protein structure, and much effort has been directed toward understanding which sequences can form helices. The helix hypothesis, introduced here, provides a tentative answer to this question. The hypothesis states that a necessary condition for helix formation is the presence of residues flanking the helix termini whose side chains can form hydrogen bonds with the initial four-helix > N.sbd.H groups and final four-helix > C.sbd.O groups; these eight groups would otherwise lack intrahelical partners. This simple hypothesis implies the existence of a stereochemical code in which certain sequences have the hydrogen-bonding capacity to function as helix boundaries and thereby enable the helix to form autonomously. The three-dimensional structure of a protein is a consequence of the genetic code, but the relating sequence to structure are still unknown. The ensuing analysis supports the idea that a stereochemical code for the .alpha. helix in its boundary residues.