Blunted exercise-induced mobilization of monocytes in somatization syndromes and major depression
Blunted exercise-induced mobilization of monocytes in somatization syndromes and major depression
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DOI：
10.1016/j.jad.2014.04.060
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发表时间：
2014-09-01
影响因子：
6.6
通讯作者：
Rief, Winfried
中科院分区：
文献类型：
--
作者：
Euteneuer, Frank;Schwarz, Markus J.;Rief, Winfried
背景：先前的研究表明，体力活动可能会改变免疫细胞的数量。我们研究是否增加或减少体力活动的水平影响循环淋巴细胞和单核细胞计数在躯体化综合征患者和patients with major depression.Methods：38名参与者与抑郁症，26名参与者与躯体化综合征和47名健康对照者参加了这项研究。使用实验受试者内设计，参与者参与1周的增加体力活动（日常锻炼）和1周的减少体力活动。在每次试验前和试验后测定淋巴细胞总数、淋巴细胞亚群和单核细胞计数。线性混合模型调整性别，体重指数，年龄，健身状态和试验的顺序被用于纵向dataanalysis.Results：一周的运动增加单核细胞的数量在健康对照组（p <0.05），但不是在躯体化综合征或重度抑郁症患者。此外，运动1周后，抑郁症患者的抑郁症状减轻（p < .05），而两个临床组的躯体形式症状减轻（p < .05）。基线比较和混合模型显示躯体化综合征患者辅助性T细胞计数减少。局限性：样本量相对较小。体力活动的时间相对较短，并限于低级别的exercise.Conclusions：这项研究表明，在躯体化综合征患者和抑郁症患者的单核细胞运动的钝化动员。此外，即使是一周的锻炼也会减少躯体形式和抑郁症状。(C)2014爱思唯尔有限公司版权所有。
Background: Previous research indicates that physical activity may alter the number of immune cells. We examined whether increasing or decreasing the level of physical activity affects circulating lymphocyte and monocyte counts in patients with somatization syndromes and patients with major depression.Methods: Thirty-eight participants with major depression, 26 participants with somatization syndromes and 47 healthy controls participated in the study. Using an experimental within-subject design, participants were involved in 1 week of increased physical activity (daily exercise sessions) and 1 week of reduced physical activity. Counts of total lymphocytes, lymphocyte subsets and monocytes were determined before and after each trial. Linear mixed models adjusted for sex, body mass index, age, fitness status and the order of trials were used for longitudinal data analysis.Results: One week of exercise increases the number of monocytes in healthy controls (p < .05), but not in patients with somatization syndromes or patients with major depression. In addition, after 1 week of exercise, depressive symptoms were reduced in patients with major depression (p < .05) while somatoform symptoms were reduced (p < .05) in both clinical groups. Baseline comparisons and mixed models indicated reduced T helper cell counts in patients with somatization syndromes.Limitations: Relatively small sample size. The time of physical activity was relatively short and restricted to low-graded exercise.Conclusions: This study demonstrates a blunted mobilization of monocytes by exercise in both patients with somatization syndromes and patients with major depression. In addition, even one week of exercise reduces somatoform and depressive symptoms. (C) 2014 Elsevier B.V. All rights reserved.