Detection of ammonia in human breath using quartz crystal microbalance sensors with functionalized mesoporous SiO2 nanoparticle films
Detection of ammonia in human breath using quartz crystal microbalance sensors with functionalized mesoporous SiO2 nanoparticle films
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DOI：
10.1016/j.snb.2015.03.103
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发表时间：
2015-08-01
影响因子：
8.4
通讯作者：
Lee, Seung-Woo
中科院分区：
文献类型：
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作者：
Ogimoto, Yusuke;Selyanchyn, Roman;Lee, Seung-Woo
制备了具有包含二氧化硅纳米粒子和聚（烯丙胺盐酸盐）（PAH）的多孔膜的石英晶体微天平（QCM）传感器。这些薄膜是通过静电自组装方法沉积的，它们对相对湿度表现出相当大的敏感性。将聚丙烯酸 (PAA) 注入多层多孔膜（5 或 10 个循环）中，可以构建用于检测气态氨的高灵敏度和选择性 QCM 传感器装置。使用带有和不带有 PAA 的两种类型的 QCM 传感器作为同时定量检测湿度和氨的传感器。对所制造的薄膜进行了全面的傅里叶变换红外（FTIR）研究，以阐明传感器设备界面处的化学相互作用的机制。进行了初步测试以检测人体呼吸中的低浓度氨，这具有临床意义。这些测试结果表明，该传感器可以检测人体呼吸中病理水平（大于3 ppm）的氨。 (C) 2015 Elsevier B.V. 保留所有权利。
Quartz crystal microbalance (QCM) sensors with porous films comprising silica nanoparticles and poly(allylamine hydrochloride) (PAH) were fabricated. The films were deposited via an electrostatic self-assembly method, and they exhibited considerable sensitivity to relative humidity. The infusion of poly(acrylic acid) (PAA) into multi-layer porous films (5 or 10 cycles) enabled the construction of a highly sensitive and selective QCM sensor device for the detection of gaseous ammonia. Two types of QCM sensors, with and without PAA, were used as sensors for the simultaneous quantitative detection of humidity and ammonia. A comprehensive Fourier transform infrared (FTIR) investigation of the fabricated films was conducted to elucidate the mechanism of the chemical interaction at the sensor device interface. Preliminary tests were conducted to detect low concentrations of ammonia in human breath, which are of clinical relevance. The results of these tests showed that the sensor can detect ammonia in human breath at pathological levels (greater than 3 ppm). (C) 2015 Elsevier B.V. All rights reserved.