Nine new compounds from the whole plants of Rehmannia chingii
Nine new compounds from the whole plants of Rehmannia chingii
复制标题
地黄全草中的九种新化合物
DOI：
10.1080/10286020.2016.1173680
复制
发表时间：
2016-01-01
影响因子：
1.7
通讯作者：
Yu, De-Quan
中科院分区：
文献类型：
--
作者：
Liu, Yan-Fei;Shi, Guo-Ru;Yu, De-Quan
从地黄全株中分离出 9 种新化合物以及 16 种已知类似物。根据光谱数据和化学证据阐明了化合物 1-9 的结构。此外，还测试了这些新化合物对 APAP 诱导的 HepG2 细胞损伤的保肝活性，以及抑制小鼠小胶质细胞 BV2 细胞系中 LPS 诱导的一氧化氮产生的能力。化合物2和5在10μM浓度下对APAP诱导的HepG2细胞损伤表现出显着的保肝活性，化合物4和9对小胶质细胞炎症因子表现出中等抑制活性，IC50值分别为3.51和7.11μM。
Nine new compounds, together with 16 known analogs, were isolated from the whole plants of Rehmannia chingii. The structures of compounds 1-9 were elucidated on the basis of their spectroscopic data and chemical evidence. In addition, the new compounds were tested for their hepatoprotective activities against APAP-induced HepG2 cell damage and their ability to inhibit LPS-induced nitric oxide production in the murine microglia BV2 cell line. Compounds 2 and 5 exhibited pronounced hepatoprotective activities against APAP-induced HepG2 cell damage at a concentration of 10 mu M, and compounds 4 and 9 showed moderate inhibitory activity against microglial inflammation factor with IC50 values of 3.51 and 7.11 mu M, respectively.