Dendritic cell‐based immunity and vaccination against hepatitis C virus infection
Dendritic cell‐based immunity and vaccination against hepatitis C virus infection
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DOI：
10.1111/j.1365-2567.2012.03590.x
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发表时间：
2012-08
期刊：
影响因子：
6.4
通讯作者：
Yun Zhou;Ying Zhang;Z. Yao;J. Moorman;Z. Jia
中科院分区：
文献类型：
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作者：
Yun Zhou;Ying Zhang;Z. Yao;J. Moorman;Z. Jia
丙型肝炎病毒 (HCV) 已长期感染全球约 1.7 亿人。开发针对 HCV 感染的有效疫苗存在许多障碍。树突状细胞（DC）仍然是宿主免疫反应中最重要的抗原呈递细胞，并且能够诱导生产性免疫或维持对自身和非自身抗原的耐受状态。研究人员最近探索了 HCV 感染期间 DC 功能受到调节的机制，导致抗病毒 T 细胞反应受损，从而导致持续的病毒感染。最近，基于 DC 的 HCV 疫苗已经开发出来。本文总结了目前对HCV感染过程中DC功能的认识，并探讨了基于DC的HCV疫苗的前景。它特别描述了DC的生物学、HCV感染患者中DC的表型、HCV对DC发育和功能的影响、抗HCV感染的新型DC疫苗的研究以及提高DC疫苗功效的策略。
Hepatitis C virus (HCV) has chronically infected an estimated 170 million people worldwide. There are many impediments to the development of an effective vaccine for HCV infection. Dendritic cells (DC) remain the most important antigen‐presenting cells for host immune responses, and are capable of either inducing productive immunity or maintaining the state of tolerance to self and non‐self antigens. Researchers have recently explored the mechanisms by which DC function is regulated during HCV infection, leading to impaired antiviral T‐cell responses and so to persistent viral infection. Recently, DC‐based vaccines against HCV have been developed. This review summarizes the current understanding of DC function during HCV infection and explores the prospects of DC‐based HCV vaccine. In particular, it describes the biology of DC, the phenotype of DC in HCV‐infected patients, the effect of HCV on DC development and function, the studies on new DC‐based vaccines against HCV infection, and strategies to improve the efficacy of DC‐based vaccines.