Mechanism of anterior pituitary tumor induction by estrogen
Mechanism of anterior pituitary tumor induction by estrogen
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雌激素诱发垂体前叶瘤的机制
DOI：
10.1002/ar.1091250106
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发表时间：
1956
期刊：
影响因子：
--
通讯作者：
R. K. Meyer
中科院分区：
文献类型：
--
作者：
K. H. Clifton;R. K. Meyer
通过长期给予含有促性腺激素的垂体制剂，首次在完整的雌性大鼠中形成垂体前叶出血性囊肿（Selye，Collip和Thompson，'33）。随后，给予妊娠尿提取物或雌激素，使雌性大鼠垂体增大（Wolfe，Phelps和Cleveland，'33 ; Wolfe，' 35 a和B），发现大鼠和小鼠在雌激素治疗几个月后出现前叶腺瘤性肿瘤（Cramer和Horning，'36; McEuen，Selye和Collip，'36; Zondek，'36）。关于短期和长期雌激素给药对垂体前叶细胞学和生理学影响的大量实验证据已经发表，并由几位作者进行了总结（Zondek，'41; Wolfe，'49; Gardner，'48和' 53）。本文试图将本实验室所观察到的雌激素诱发垂体瘤的发生与其他人的大量工作联系起来，并提出一个可能对垂体瘤形成的病因学研究有用的工作假说。
Hemorrhagic cysts of the anterior pituitary were first developed in intact, female rats by the prolonged administration of a pituitary preparation containing gonadotrophins (Selye, Collip and Thompson, '33). Subsequently, enlargement of the pituitaries of female rats was obtained with the administration of an extract of pregnancy urine or estrin (Wolfe, Phelps and Cleveland, '33 ; Wolfe, '35a and b), and adenomatous tumors of the anterior lobe were found to develop in rats and mice following several months of estrogen treatment (Cramer and Horning, '36; McEuen, Selye and Collip, '36; Zondek, '36). A large body of experimental evidence on the effects of short and long term estrogen administration on the cytology and physiology of the anterior pituitary has since been published, and has been summarized by several authors (Zondek, '41; Wolfe, '49; Gardner, '48 and ' 5 3 ) . The present report is an attempt to relate the observations on estrogen-induced pituitary tumorigenesis obtained in our laboratory to the extensive work of others, and to present a working hypothesis which may be of use in studies on the etiolo-gy of pituitary tumor formation.