Early life stress, cortisol, frontolimbic connectivity, and depressive symptoms during puberty
Early life stress, cortisol, frontolimbic connectivity, and depressive symptoms during puberty
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DOI：
10.1017/s0954579419000555
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发表时间：
2019-08-01
影响因子：
3.3
通讯作者：
Gotlib, Ian H.
中科院分区：
文献类型：
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作者：
Kircanski, Katharina;Sisk, Lucinda M.;Gotlib, Ian H.
早期生活压力（ELS）是青少年抑郁发展的危险因素；然而，介导的神经生物学机制尚不清楚。在这项研究中，我们研究了青春期早期青少年的ELS、皮质醇应激反应和钩状束和穹窿这两个关键额叶束的白质微观结构之间的关系；我们还测试了这些变量是否以及如何预测青春期后期的抑郁症状。共有208名参与者（117名女性，M年龄= 11.37岁，M Tanner分期= 2.03）提供了两种或多种评估模式的数据：ELS；心理社会应激任务中的唾液皮质醇水平；扩散磁共振成像；还有抑郁症状。在青春期早期，高ELS与皮质醇分泌减少之间存在显著关联，皮质醇分泌减少与钩侧束分数各向异性增加之间存在显著关联。此外，钩状束分数各向异性的增加预示着青春期后期抑郁症状的增加，高于早期症状。在事后分析中，我们发现性别调节了几个额外的关联。我们在一个更广泛的概念模型中讨论了这些发现，该模型将ELS、情绪失调和青春期过渡期间的抑郁联系起来，并认为与控制下丘脑-垂体-肾上腺轴功能有关的脑回路应该是继续研究的重点。
Early life stress (ELS) is a risk factor for the development of depression in adolescence; the mediating neurobiological mechanisms, however, are unknown. In this study, we examined in early pubertal youth the associations among ELS, cortisol stress responsivity, and white matter microstructure of the uncinate fasciculus and the fornix, two key frontolimbic tracts; we also tested whether and how these variables predicted depressive symptoms in later puberty. A total of 208 participants (117 females; M age = 11.37 years; M Tanner stage = 2.03) provided data across two or more assessment modalities: ELS; salivary cortisol levels during a psychosocial stress task; diffusion magnetic resonance imaging; and depressive symptoms. In early puberty there were significant associations between higher ELS and decreased cortisol production, and between decreased cortisol production and increased fractional anisotropy in the uncinate fasciculus. Further, increased fractional anisotropy in the uncinate fasciculus predicted higher depressive symptoms in later puberty, above and beyond earlier symptoms. In post hoc analyses, we found that sex moderated several additional associations. We discuss these findings within a broader conceptual model linking ELS, emotion dysregulation, and depression across the transition through puberty, and contend that brain circuits implicated in the control of hypothalamic-pituitary-adrenal axis function should be a focus of continued research.