Anxiety risk SNPs on chromosome 2 modulate arousal in children in a fear generalization paradigm
Anxiety risk SNPs on chromosome 2 modulate arousal in children in a fear generalization paradigm
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DOI：
10.1007/s00787-019-01458-7
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发表时间：
2019-12-21
影响因子：
6.4
通讯作者：
Romanos, Marcel
中科院分区：
文献类型：
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作者：
Reinhard, Julia;Drepper, Carsten;Romanos, Marcel
恐惧学习/泛化的改变被认为是导致焦虑症发展的相关机制，焦虑症是最普遍的精神障碍。虽然焦虑症几乎都是在儿童和青少年时期首次发病，但病因学研究主要集中在成年人身上。在这项研究中，我们评估了最近一项对成人焦虑症全基因组关联研究的荟萃分析结果，该研究发现，在347名以维度焦虑为特征的健康儿童（8-12岁）中，四种单核苷酸多态性（SNPs）存在显著关联。在迄今为止最大的儿童样本中，我们研究了这些snp在歧视性恐惧条件反射和泛化范式中对焦虑参数的调节。结果扩展了荟萃分析的发现，显示2p21上的基因组位点调节焦虑人格特征和唤醒评级。因此，这些snp可能作为病理性焦虑共有风险的易感性标记，可能是由觉醒的改变介导的。
Alterations in fear learning/generalization are considered to be relevant mechanisms engendering the development of anxiety disorders being the most prevalent mental disorders. Although anxiety disorders almost exclusively have their first onset in childhood and adolescence, etiological research focuses on adult individuals. In this study, we evaluated findings of a recent meta-analysis of genome-wide association studies in adult anxiety disorders with significant associations of four single nucleotide polymorphisms (SNPs) in a large cohort of 347 healthy children (8-12 years) characterized for dimensional anxiety. We investigated the modulation of anxiety parameters by these SNPs in a discriminative fear conditioning and generalization paradigm in the to-date largest sample of children. Results extended findings of the meta-analysis showing a genomic locus on 2p21 to modulate anxious personality traits and arousal ratings. These SNPs might, thus, serve as susceptibility markers for a shared risk across pathological anxiety, presumably mediated by alterations in arousal.