Outcome of partial hepatectomy for large (>10 cm) hepatocellular carcinoma
Outcome of partial hepatectomy for large (>10 cm) hepatocellular carcinoma
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DOI：
10.1002/cncr.21415
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发表时间：
2005-11-01
期刊：
影响因子：
6.2
通讯作者：
DeMatteo, RP
中科院分区：
文献类型：
--
作者：
Liau, KH;Ruo, L;DeMatteo, RP
背景。许多人认为手术切除大的（> 10 cm）肝细胞癌（HCC）是无效的。本研究的目的是回顾大型 HCC 患者部分肝切除术的结果。方法。 1985 年至 2002 年间，从前瞻性数据库中确定了 193 名连续接受部分肝切除术的 HCC 患者。将 82 名肿瘤 > 10 厘米的患者与其余肿瘤 2 升的患者进行多变量分析预测总生存期进行比较。结论。部分肝切除术对于大型 HCC 患者是安全的。在选定的大肿瘤患者中，切除术可实现与较小肿瘤患者相似的总生存期和无复发生存期。最大程度地减少术中失血对于大型 HCC 患者的长期预后至关重要。
BACKGROUND. Surgical resection for large (> 10 cm) hepatocellUlar carcinoma (HCC) is believed by many to be ineffective. The objective of the current study was to review the outcome of partial hepatectomy in patients with large HCC.METHODS. Between 1985 and 2002, 193 consecutive patients who underwent partial hepatectomy for HCC were identified from a prospective database. The 82 patients with tumors > 10 cm were compared with the remaining Ill patients with 2 liters predicted overall survival on multivariate analysis.CONCLUSIONS. Partial hepatectomy is safe for patients with large HCC. In selected patients with large tumors, resection achieves similar overall survival and recurrence-free survival to that of patients with smaller tumors. Minimizing intraoperative blood loss appears to be critical for favorable long-term outcome in patients with large HCC.