Arterial blood gases predict long-term prognosis in stage I non-small cell lung cancer patients.
Arterial blood gases predict long-term prognosis in stage I non-small cell lung cancer patients.
复制标题
动脉血气可以预测I期非小细胞肺癌患者的长期预后。
DOI：
10.1186/s12893-016-0119-4
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发表时间：
2016-01-13
期刊：
影响因子：
1.9
通讯作者：
Nishiyama N
中科院分区：
文献类型：
--
作者：
Mizuguchi S;Iwata T;Izumi N;Tsukioka T;Hanada S;Komatsu H;Nishiyama N
据报道，术前高碳酸血症和低氧血症是术后并发症的危险因素。本研究旨在确定非小细胞肺癌（NSCLC）患者与术前动脉血气（ABG）异常相关的长期生存风险。本研究涉及414例接受肺叶切除术/双叶切除术和纵隔淋巴结清扫术的I期NSCLC患者。将患者分为ABG正常组（n = 269）和异常组（n = 145）。ABG正常组患者（中位年龄67岁）明显年轻于ABG异常组患者（中位年龄70岁）。除慢性阻塞性肺疾病/肺纤维化外，两组在性别、体能状态、病理分期、组织学、术后并发症或术前合并症方面无显著差异。ABG正常组和异常组的3年、5年和10年生存率分别为87、77和56%，以及78、63和42%（p = 0. 006）。多因素分析显示，年龄、性别、体力状态、非腺癌、肿瘤分化程度、病理分期、既往肿瘤史和ABG异常（危险比1.61）是影响预后的独立因素。ABG异常可预测NSCLC患者的长期生存风险，这对制定治疗策略具有重要意义。
Preoperative hypercapnia and hypoxemia are reportedly risk factors for postoperative complications. This study aimed to establish the long-term survival risk associated with abnormal preoperative arterial blood gases (ABGs) in patients with non-small cell lung cancer (NSCLC). This study involved 414 patients with stage I NSCLC who underwent lobectomy/bilobectomy with mediastinal lymph node dissection. The patients were divided into groups with normal (n = 269) and abnormal (n = 145) ABGs. The patients in the normal ABG group (median age 67 years) were significantly younger than those in the abnormal ABG group (median age 70 years). There were no significant differences between the groups in gender, performance status, pathological stage, histology, postoperative complications, or preoperative comorbidity, except for chronic obstructive pulmonary disease/pulmonary fibrosis. The 3-, 5- and 10-year survival rates in the normal and abnormal ABG groups were 87, 77 and 56, and 78 , 63 and 42 %, respectively (p = 0.006). According to multivariate analysis, age, gender, performance status, non-adenocarcinoma, differentiation of resected tumor, pathological stage, any prior tumor and abnormal ABGs (risk ratio, 1.61) were independent prognostic factors. Abnormal ABGs predict long-term survival risk in patients with NSCLC, which is important for planning therapeutic strategies.