Transient leukemoid proliferation of the cytogenetically unbalanced +21 cell line of a constitutional mosaic boy.
Transient leukemoid proliferation of the cytogenetically unbalanced +21 cell line of a constitutional mosaic boy.
复制标题
体质镶嵌男孩细胞遗传学不平衡的 21 细胞系的短暂类白血病增殖。
作者：
D. Heaton;P. H. Fitzgerald;G. Fraser;G. Abbott
一名没有任何唐氏综合症症状的新生儿被发现患有急性增殖症，无需药物治疗即可缓解。对血液、骨髓和皮肤细胞的染色体分析显示，这个孩子是一个由正常细胞和少量细胞组成的镶嵌体，其中没有一个细胞。 21 号染色体被可能为 21 号的同染色体替换。 21长臂：46，XY/46，XY，i(21q)。嵌合体的异常细胞系似乎选择性地参与了这种增殖。
A newborn without any signs of Down's syndrome was found to have an acute proliferation that remitted without drug therapy. Chromosomal analysis of blood, bone marrow, and skin cells revealed that the child was a constitutional mosaic with normal cells and a low number of cells in which one no. 21 chromosome was replaced by a probably isochromosome for the no. 21 long arm: 46,XY/46,XY,i(21q). The abnormal cell line of the mosaic appeared to be selectively involved in this proliferation.