Quantitative analysis of coronary endothelial function with generator-produced 82Rb PET: comparison with 15O-labelled water PET
Quantitative analysis of coronary endothelial function with generator-produced 82Rb PET: comparison with 15O-labelled water PET
复制标题
使用发生器产生的 82Rb PET 定量分析冠状动脉内皮功能：与 15O 标记的水 PET 比较
DOI：
10.1007/s00259-010-1541-y
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发表时间：
2010
影响因子：
9.1
通讯作者：
N. Tamaki
中科院分区：
文献类型：
--
作者：
K. Yoshinaga;O. Manabe;C. Katoh;Li Chen;R. Klein;M. Naya;R. deKemp;K. Williams;R. Beanlands;N. Tamaki
目的内皮功能障碍是冠状动脉粥样硬化发展过程中最早的异常。82 Rb是一种发生器产生的正电子发射断层扫描（PET）心肌灌注示踪剂，其使用越来越广泛。我们的目的是（1）开发一种方法，用于定量评估冠状动脉内皮功能的心肌血流量（MBF）的反应，在冷加压试验（CPT）在吸烟者，使用82 Rb PET测量，和（2）比较结果与15 O-水PET.MethodsMBF的测量结果进行了评估，在休息和CPT期间与82 Rb和15 O-水在9个控制和10个吸烟者。一室模型与示踪剂提取校正用于估计MBF与两种示踪剂。CPT反应计算的MBF在CPT MBF的比率在rest.ResultsAt休息时，测量MBF吸烟者与对照组使用15 O-水（0.86 ± 0.18比0.70 ± 0.13，p = 0.426）比他们使用82 Rb（0.83 ± 0.23比0.62 ± 0.20，p = 0.051）没有什么不同。两种方法均显示吸烟者与对照组相比CPT反应降低（15 O-水，1.03 ± 0.21 vs 1.42 ± 0.29，p = 0.006; 82 Rb，1.02 ± 0.28 vs 1.70 ± 0.52，p < 0.001）。有较高的可靠性[组内相关系数：0.48（0.07，0.75）]的MBF测量之间的82 Rb和15 O-水在CPT.ConclusionUsing CPT，82 Rb MBF测量检测吸烟者冠状动脉内皮功能障碍。82 Rb MBF测量值与使用15 O-水方法进行的测量值相当。因此，82 Rb PET可能适用于具有冠状动脉危险因素的受试者的风险评估或风险因素修改的评价。
PurposeEndothelial dysfunction is the earliest abnormality in the development of coronary atherosclerosis. 82Rb is a generator-produced positron emission tomography (PET) myocardial perfusion tracer that is becoming more widely used. We aimed to (1) develop a method for quantitative assessment of coronary endothelial function using the myocardial blood flow (MBF) response during a cold pressor test (CPT) in smokers, measured using 82Rb PET, and (2) compare the results with those measured using 15O-water PET.MethodsMBF was assessed at rest and during the CPT with 82Rb and 15O-water in nine controls and ten smokers. A one-compartment model with tracer extraction correction was used to estimate MBF with both tracers. CPT response was calculated as the ratio of MBF during the CPT to MBF at rest.ResultsAt rest, measurements of MBF for smokers vs controls were not different using 15O-water (0.86 ± 0.18 vs 0.70 ± 0.13, p = 0.426) than they were using 82Rb (0.83 ± 0.23 vs 0.62 ± 0.20, p = 0.051). Both methods showed a reduced CPT response in smokers vs controls (15O-water, 1.03 ± 0.21 vs 1.42 ± 0.29, p = 0.006; 82Rb, 1.02 ± 0.28 vs 1.70 ± 0.52, p < 0.001). There was high reliability [intraclass correlation coefficients: 0.48 (0.07, 0.75)] of MBF measurement between 82Rb and 15O-water during the CPT.ConclusionUsing a CPT, 82Rb MBF measurements detected coronary endothelial dysfunctions in smokers. 82Rb MBF measurements were comparable to those made using the 15O-water approach. Thus, 82Rb PET may be applicable for risk assessments or evaluation of risk factor modification in subjects with coronary risk factors.