Effects of weight loss on a low-carbohydrate diet on flow-mediated dilatation, adhesion molecules and adiponectin
Effects of weight loss on a low-carbohydrate diet on flow-mediated dilatation, adhesion molecules and adiponectin
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DOI：
10.1017/s0007114507747815
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发表时间：
2007-10-01
影响因子：
3.6
通讯作者：
Clifton, Peter M.
中科院分区：
文献类型：
--
作者：
Keogh, Jennifer B.;Brinkworth, Grant D.;Clifton, Peter M.
Our aim was to determine whether short-term weight loss on a low-carbohydrate/low-saturated fat diet improved endothelial function compared with a conventional high-carbohydrate diet, as this diet is expected to lower both blood glucose and LDL-cholesterol. In a randomised parallel design of two energy-restricted diets in an outpatient setting, thirty-six subjects (BMI 33 (SEM 4) kg/m(2)) were randomised to a low- or high-carbohydrate diet both low in saturated fat. Flow-mediated dilatation (FMD), fasting glucose, insulin, lipids, adiponectin and adhesion molecules were measured at baseline, during weight loss and at 52 weeks. FMD did not change with either diet (5.2 (SEM 0.6) to 5.5 (SEM 0.6) %) despite weight loss of 5% and significant reductions in glucose and insulin and LDL-cholesterol and was not different after sustained weight loss of 5% at 52 weeks. Adiponectin fell by 6% at 12 weeks (P=0.1) with weight loss but rose by 17% at 12 months (P
