Human Cytokine-Induced Memory-Like Natural Killer Cells.
Human Cytokine-Induced Memory-Like Natural Killer Cells.
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DOI：
10.1159/000382019
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发表时间：
2015
影响因子：
5.3
通讯作者：
Fehniger TA
中科院分区：
文献类型：
--
作者：
Berrien-Elliott MM;Wagner JA;Fehniger TA
NK细胞是天然的淋巴样细胞，对宿主抵抗感染和介导抗肿瘤反应具有重要作用。最近来自几个实验室的报告已经证实，NK细胞可以记住先前的激活事件，因此在再次受到刺激时反应更强劲，这种特性被称为先天NK细胞记忆。在半抗原暴露、病毒感染和细胞因子预激活与IL-12、IL-15和IL-18相结合后，NK细胞的记忆现在已经被发现。该领域的许多问题仍然是关于调节记忆NK细胞及其反应的细胞和分子机制，以及它们在小鼠和人类中的形成和功能。在这里，我们回顾了我们目前对细胞因子诱导的类记忆(CIML)NK细胞的理解，它是由IL-12、IL-15和IL-18联合预激活而产生的。这些细胞在初始细胞因子预激活几周后表现出增强的NK细胞效应功能。此外，我们强调了CIML NK细胞用于血液肿瘤患者过继免疫治疗的临床前理论基础和正在进行的治疗应用。
NK cells are innate lymphoid cells that are important for host defense against infection and mediate anti-tumor responses. Recent reports from several laboratories have identified that NK cells can remember a prior activation event and consequently respond more robustly when re-stimulated, a property termed innate NK cell memory. NK cell memory has now been identified following hapten exposure, viral infection, and combined cytokine pre-activation with IL-12, IL-15 and IL-18. Many questions in the field remain regarding the cellular and molecular mechanisms regulating memory NK cells and their responses, as well as their formation and function in mice and humans. Here we review our current understanding of cytokine-induced memory-like (CIML) NK cells that are generated by combined pre-activation with IL-12, IL-15 and IL-18. These cells exhibit enhanced NK cell effector functions weeks after the initial cytokine pre-activation. Further, we highlight the pre-clinical rationale and ongoing therapeutic application of CIML NK cells for adoptive immunotherapy in patients with hematologic malignancies.