A Ca-deficientca-deficient hydroxyapatite (CDHA)/MgF2 bi-layer coating with unique nano-scale topography on biodegradable high-purity Mg
A Ca-deficientca-deficient hydroxyapatite (CDHA)/MgF2 bi-layer coating with unique nano-scale topography on biodegradable high-purity Mg
复制标题
一种缺钙羟基磷灰石 (CDHA)/MgF2 双层涂层，在可生物降解的高纯镁上具有独特的纳米级形貌
DOI：
10.1016/j.colsurfb.2020.110911
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发表时间：
2020-06-01
影响因子：
5.8
通讯作者：
Yang, Ke
中科院分区：
文献类型：
--
作者：
Li, Junlei;Xu, Wenwu;Yang, Ke
提高镁合金的耐腐蚀性和促进新骨的形成，使其成为理想的骨生物材料。为此，采用氟化处理和水热处理相结合的方法在高纯镁表面制备了CDHA/MgF 2双层涂层。涂层呈现出纳米级的表面形貌。CDHA/MgF 2双层涂层的结合强度和耐蚀性得到了提高。体外细胞实验表明，与HA涂层和MgF 2涂层的Mg相比，CDHA/MgF 2涂层的Mg对MG 63细胞的粘附、增殖和分化均有显著提高。总之，本研究提供了一种有前途的表面改性方法，提高镁金属的耐腐蚀性和优良的上级成骨生物活性。
Enhanced corrosion resistance and accelerated new bone formation are desired to make Mg and its alloys to be ideal candidate for bone biomaterial. For this purpose, a CDHA/MgF2 bi-layer coating was prepared on high purity Mg by a combination of fluoride treatment and hydrothermal treatment. The coating exhibited a nanoscale surface topography. Enhanced adhesion strength and corrosion resistance was obtained for the CDHA/MgF2 bi-layer coating. In vitro cell experiment showed that the adhesion, proliferation and differentiation of MG63 cells were significantly improved on Mg with CDHA/MgF2 coating compared to that on Mg with HA coating and MgF2 coating. In conclusion, this study provides a promising surface modification method for Mg metal with enhanced corrosion resistance and superior osteogenic bioactivity.