Plasma concentrations of Gas6 and soluble Axl correlate with disease and predict mortality in patients with critical limb ischemia
Plasma concentrations of Gas6 and soluble Axl correlate with disease and predict mortality in patients with critical limb ischemia
复制标题
DOI：
10.1016/j.clinbiochem.2010.04.006
复制
发表时间：
2010-07-01
影响因子：
2.8
通讯作者：
Dahlback, Bjorn
中科院分区：
文献类型：
--
作者：
Ekman, Carl;Gottsater, Anders;Dahlback, Bjorn
简介：严重肢体缺血（CLI）是一种严重的外周动脉疾病，其特征是腿部静息痛、溃疡和坏疽。Gas 6是维生素K依赖性蛋白，其结合并激活酪氨酸激酶受体Axl。Gas 6介导的Axl信号传导影响内皮活化、新生内膜形成和免疫调节。实验设计和方法：我们对189例CLI患者和204例对照者的血浆Gas 6和sAxl浓度进行了定量分析。结果：CLI患者血浆Gas 6和sAxl浓度升高（P < 0.05），而对照组血浆Gas 6和sAxl浓度升高（P < 0.05）。
Introduction: Critical limb ischemia (CLI) is a severe peripheral arterial disease, characterized by rest pain, ulcers and gangrene in the legs. Gas6 is a vitamin K-dependent protein, which binds and activates the tyrosine kinase receptor Axl. Gas6-mediated Axl-signaling influences endothelial activation, neointima formation and immune regulation. Axl can be cleaved and soluble Axl (sAxl) is detectable in circulation.Design and methods: We quantified plasma concentrations of Gas6 and sAxl in 189 CLI patients and 204 controls.Results: Gas6 and sAxl concentrations were increased in the CLI patients (p