Control of epithelial cell shape and polarity
Control of epithelial cell shape and polarity
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DOI：
10.1016/s0959-437x(00)00115-5
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发表时间：
2000-10-01
影响因子：
4
通讯作者：
Knust, E
中科院分区：
文献类型：
--
作者：
Knust, E
细胞的极化特征从其形状上通常是显而易见的，并且在很大程度上依赖于肌动蛋白细胞骨架和与膜相关的细胞皮质--一个由血影蛋白和其他相关蛋白质组成的致密网络。空间和功能上不同的蛋白质支架，由跨膜和细胞质蛋白质组装而成，为极化提供线索。最近的数据为这些信号的分子性质以及它们可能被转化为极化表型的机制提供了新的见解。
The polarised character of a cell is often obvious from its shape and is largely dependent on the actin cytoskeleton and the membrane-associated cell cortex - a dense network comprising spectrin and other related proteins. Spatially and functionally distinct protein scaffolds, assembled from transmembrane and cytoplasmic proteins, provide the cues for polarisation. Recent data have provided new insights into the molecular nature of these cues and the mechanisms by which they may be translated into a polarised phenotype.