DIFFERENTIAL EFFECT OF ACUTE AND CHRONIC ETHANOL ON DOPAMINE METABOLISM IN FRONTAL-CORTEX, CAUDATE-NUCLEUS AND SUBSTANTIA-NIGRA
DIFFERENTIAL EFFECT OF ACUTE AND CHRONIC ETHANOL ON DOPAMINE METABOLISM IN FRONTAL-CORTEX, CAUDATE-NUCLEUS AND SUBSTANTIA-NIGRA
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DOI：
10.1016/0024-3205(80)90108-3
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发表时间：
1980-01-01
期刊：
影响因子：
6.1
通讯作者：
GESSA, GL
中科院分区：
文献类型：
--
作者：
FADDA, F;ARGIOLAS, A;GESSA, GL
对正常大鼠急性口服乙醇（3.2 g/kg）可增加尾状核中的多巴[3，4-二羟基苯乙酸]水平和多巴形成，但对黑质和额叶皮质没有影响，并且未能改变上述任何脑区的多巴胺（DA）水平。对多巴形成的刺激作用的完全耐受性在长期乙醇给药（每天3.2g，持续60天）后形成。在长期治疗的大鼠中，乙醇戒断后24小时，额叶皮质中的DA水平比对照组高60%，黑质和尾状核中的DA水平没有变化，所有研究区域的多巴酚酸水平也没有变化。乙醇的管理引起了长期持久的消耗DA和平行增加多巴酚水平在所有领域的分析。急性和慢性乙醇释放DA储存，但在急性条件下，DA消耗是防止增加合成。
Acute oral administration of ethanol (3.2 g/kg) to normal rats increased dopac [3,4-dihydroxyphenylacetic acid] levels and dopa formation in the caudate nucleus, but had no effect in the substantia nigra and frontal cortex, and failed to modify dopamine (DA) levels in any of the above brain areas. Complete tolerance to the stimulant effect on dopa formation developed after chronic ethanol administration (3.2 g daily for 60 days). In chronically treated rats, 24 h after ethanol withdrawal, DA levels in the frontal cortex were 60% higher than in controls, and were unchanged in the substantia nigra and caudate nucleus, as were dopac levels in all areas studied. The administration of ethanol caused a long lasting depletion of DA and a parallel increase of dopac levels in all areas analyzed. Acute and chronic ethanol release DA stores but, in the acute condition, DA depletion is prevented by increased synthesis.