A primitive T cell-independent mechanism of intestinal mucosal IgA responses to commensal bacteria
A primitive T cell-independent mechanism of intestinal mucosal IgA responses to commensal bacteria
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DOI：
10.1126/science.288.5474.2222
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发表时间：
2000-06-23
期刊：
影响因子：
56.9
通讯作者：
Zinkernagel, RM
中科院分区：
文献类型：
--
作者：
Macpherson, AJ;Gatto, D;Zinkernagel, RM
免疫球蛋白 A (IgA) 的产生是为了保护粘膜表面免受环境生物的侵害，但宿主对肠道共生微生物的大量负荷的防御机制知之甚少。分析针对肠道共生细菌抗原的 IgA；它不仅仅是“天然抗体”，而是被特异性诱导并对已建立的肠道菌群内的抗原变化做出反应。与针对外毒素的 IgA 反应相反，这种特异性抗共生 IgA 诱导的很大一部分是通过独立于 T 细胞帮助和滤泡淋巴组织组织的途径，这可能反映了特异性免疫防御的进化原始形式。
The immunoglobulin A (IgA) is produced to defend mucosal surfaces from environmental organisms, but host defenses against the very heavy load of intestinal commensal microorganisms are poorly understood. The IgA against intestinal commensal bacterial antigens was analyzed; it was not simply "natural antibody" but was specifically induced and responded to antigenic changes within an established gut flora. In contrast to IgA responses against exotoxins, a significant proportion of this specific anti-commensal IgA induction was through a pathway that was independent of T cell help and of follicular lymphoid tissue organization, which may reflect an evolutionarily primitive form of specific immune defense.