Genetic transformation of mosquitoes: a quest for malaria control
Genetic transformation of mosquitoes: a quest for malaria control
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DOI：
10.1016/s0020-7519(02)00188-1
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发表时间：
2002-12-04
影响因子：
4
通讯作者：
Jacobs-Lorena, M
中科院分区：
文献类型：
--
作者：
Moreira, LA;Ghosh, AK;Jacobs-Lorena, M
疟疾造成巨大的人命损失，而且这一负担正在增加。目前对抗这种疾病的手段，如药物和杀虫剂是不够的。此外，有效的疫苗尚未研制出来。这篇综述探讨了疟疾控制的另一种策略，即对蚊子进行基因改造，使其成为疟原虫的低效载体。本文综述了用于种系转化的转座因子载体的开发和转化标记的研究进展。本文还综述了抗疟效应基因的研究进展，这些基因的产物能够以最小的适应度负担抑制疟原虫在蚊子体内的发育。虽然取得了很大进展，但仍有许多工作要做。展望了未来的研究方向。(C) 2002年由爱思唯尔科学有限公司代表澳大利亚寄生虫学学会出版。
Malaria inflicts an enormous toll in human lives and this burden is increasing. Present means to fight the disease, such as drugs and insecticides, are insufficient. Moreover, an effective vaccine has not yet been developed. This review examines an alternative strategy for malaria control, namely the genetic modification of mosquitoes to make them inefficient vectors for the parasite. The article summarises progress made toward the development of transposable element vectors for germ line transformation and the search for mosquito markers of transformation. Also reviewed is the search for anti-malarial effector genes whose products can inhibit development of the parasite in the mosquito with minimal fitness burden. While much progress has been made, much work remains to be done. Future research directions are discussed. (C) 2002 Published by Elsevier Science Ltd. on behalf of Australian Society for Parasitology Inc.