Galloyl group is not necessary for a sedative effect of catechin through GABAergic system
Galloyl group is not necessary for a sedative effect of catechin through GABAergic system
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DOI：
10.2174/157018007780077444
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发表时间：
2007-04-01
影响因子：
1
通讯作者：
Furuse, Mitsuhiro
中科院分区：
文献类型：
--
作者：
Adachi, Nami;Tomonaga, Shozo;Furuse, Mitsuhiro
(-)-表没食子儿茶素没食子酸酯(EGCG)通过大脑中的伽马氨基丁酸(GABA)(A)受体发挥镇静作用，但尚不清楚其作用所需的分子结构成分。为了探讨没食子酸基在EGCG镇静作用中的必要性，比较了EGCG和去掉没食子酰基的表没食子儿茶素(EGC)的镇静作用。脑室内(i.c.v.)GABA(A)受体拮抗剂印防己毒素可阻断注射EGCG和EGC的作用。结论：儿茶素在急性应激条件下通过GABA(A)受体发挥镇静作用，而与没食子酸基的存在无关。
(-)-Epigallocatechin gallate (EGCG) has a sedative effect acting through gamma-aminobutyric acid (GABA)(A) receptors in the brain, but it is unclear what structural components of the molecule are necessary for its action. To investigate the necessity of the galloyl group on the sedation induced by EGCG, the effect of EGCG was compared with (-)-epigallocatechin (EGC) in which the galloyl group is removed from EGCG. Intracerebroventricular (i.c.v.) injection of EGC, as well as EGCG, induced, and the effect of EGC were blocked by the GABA(A) receptor antagonist picrotoxin. It is concluded that catechins have a sedative effect acting through GABA(A) receptors under an acute stress condition irrespective of the presence of the galloyl group.