CASE-CONTROL STUDY OF PASSIVE SMOKING AND THE RISK OF SMALL-FOR-GESTATIONAL-AGE AT TERM
CASE-CONTROL STUDY OF PASSIVE SMOKING AND THE RISK OF SMALL-FOR-GESTATIONAL-AGE AT TERM
复制标题
DOI：
10.1093/oxfordjournals.aje.a117614
复制
发表时间：
1995-07-15
影响因子：
5
通讯作者：
PETITTI, DB
中科院分区：
文献类型：
--
作者：
CHEN, LH;PETITTI, DB
研究人员对怀孕期间被动吸烟对胎儿生长的影响进行了一项病例对照研究，研究了母亲在怀孕期间被动吸烟与足月小胎龄婴儿（SGA）风险之间的关系，研究对象是一群白人妇女，她们在怀孕期间不吸烟，只有一小部分人使用非法药物和酒精，总共有111例。定义为出生体重小于或等于胎龄第10百分位的单胎足月（大于或等于37周）婴儿与124个足月非sga对照组进行比较。所有的人都是从1991年1月1日至9月30日在加利福尼亚州康特拉科斯塔的出生证明中确定的，受试者面对面访谈以收集怀孕期间被动吸烟暴露的信息，怀孕期间被动吸烟暴露的估计相对风险与妊娠期间被动吸烟暴露相关（大于或等于30小时）没有增加；优势比（OR) = 0.41, 95%可信区间（CI） 0.12-1.29），长期SGA风险不随被动吸烟暴露时间的增加而增加。在多变量分析中，控制胎次、体重增加、孕前体重、产妇年龄、产前护理、教育程度、收入、饮酒和孕期工作没有改变结果（大于或等于30小时：or = 0.47, 95% CI 0.13-1.69）。在这项研究中，母亲在怀孕期间暴露于被动吸烟与足月SGA风险增加无关。尽管精确评估暴露程度的困难限制了这些发现，但它们应该为那些在怀孕期间无法避免被动接触香烟的妇女提供一些安慰，
There is concern about the effects of passive smoking during pregnancy on fetal growth, The authors conducted a case-control study of the association of maternal exposure to passive smoking during pregnancy and the risk of term small-for-gestational-age (SGA) infants in a population of white women who did not smoke during pregnancy and had only a small percentage of users of illegal drugs and alcohol, A total of 111 cases, defined as singleton term (greater than or equal to 37 weeks) infants with birth weights less than or equal to 10th percentile for gestational age were compared with 124 term, non-SGA controls. All were identified from Contra Costa, California birth certificates for January 1-September 30, 1991, Subjects were interviewed face-to-face to collect information on exposure to passive smoking during pregnancy, The estimated relative risk for term SGA in association with passive smoke exposure during pregnancy was not increased (greater than or equal to 30 hours: odds ratio (OR) = 0.41, 95% confidence interval (CI) 0.12-1.29) and the risk of term SGA did not increase with increasing hours of exposure to passive smoking. Controlling for parity, weight gain, prepregnancy weight, maternal age, prenatal care, education, income, alcohol consumption, and work during pregnancy in multivariate analysis did not change the findings (greater than or equal to 30 hours: OR = 0.47, 95% CI 0.13-1.69). In this study, maternal exposure to passive smoking during pregnancy was not associated with an increased risk of term SGA. Although difficulties in precisely assessing exposure limit these findings, they should provide some reassurance to women who cannot avoid passive exposure to cigarette smoking during pregnancy,