Correlation between Ultrasound Elastography and Histologic Characteristics of Papillary Thyroid Carcinoma.
Correlation between Ultrasound Elastography and Histologic Characteristics of Papillary Thyroid Carcinoma.
复制标题
超声弹性成像与甲状腺乳头状癌组织学特征的相关性
DOI：
10.1038/srep45042
复制
发表时间：
2017-03-22
影响因子：
4.6
通讯作者：
Bing H
中科院分区：
文献类型：
--
作者：
Yi L;Qiong W;Yan W;Youben F;Bing H
本研究的目的是探讨弹性成像和组织学特征（包括纤维化和钙化）之间的相关性。我们也想探讨其他临床病理指标是否影响甲状腺乳头状癌（PTC）的应变比（SR）。我们回顾性分析了103例术前接受超声和弹性成像的126例甲状腺乳头状癌（PTC）。将其组织学特征和临床病理指标与超声弹性成像（UE）的SR进行比较。结果显示，纤维化程度与SR测量值之间存在显著正相关（r = 0.754，p = 0.000）;有和无钙化组之间的SR存在显著差异（11.34 ± 10.08 vs. 6.81 ± 7.33，p = 0.000）。胶原和间质钙化的标准相关系数分别为0.684和0.194。SR与肿瘤大小、部位、是否合并桥本甲状腺炎、多灶性、颈淋巴结转移等指标无明显相关性。因此，我们发现UE的SR与PTC的纤维化呈正相关。间质钙化会使SR显著升高，但当没有间质钙化时，沙瘤体不会。
The aim of this study was to investigate the correlation between elastography and histologic characteristics including fibrosis and calcification. We also wanted to investigate whether other clinicopathologic indexes influence the strain ratio (SR) of papillary thyroid carcinomas (PTCs). We retrospectively reviewed 126 papillary thyroid carcinomas (PTCs) from 103 patients who underwent ultrasonography and elastography before surgery. The histologic characteristics and clinicopathologic indexes were compared with the SR of ultrasound elastography (UE). The results showed that there was a significantly positive correlation between fibrosis degree and SR measurements (r = 0.754, p = 0.000); the SR was significantly different between the groups with and without calcification (11.34 ± 10.08 vs. 6.81 ± 7.33, p = 0.000). The standard coefficients of collagen and stromal calcification were 0.684 and 0.194, respectively. There was no significant correlation between SR and indices such as size, position, co-existence with Hashimoto’s thyroiditis (HT), multifocality or cervical lymph node (CLN) metastasis. In conclusion, we found that the SR of UE is positively correlated with the fibrosis of PTC. Stromal calcification will elevate the SR dramatically, but psammoma bodies will not when they exist in the absence of stromal calcification.