Radiation Pneumonitis Following Twice-daily Radiotherapy with Concurrent Carboplatin and Paclitaxel in Patients with Stage III Non-small-cell Lung Cancer
Radiation Pneumonitis Following Twice-daily Radiotherapy with Concurrent Carboplatin and Paclitaxel in Patients with Stage III Non-small-cell Lung Cancer
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DOI：
10.1093/jjco/hyp190
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发表时间：
2010-05-01
影响因子：
2.4
通讯作者：
Ito, Hisao
中科院分区：
文献类型：
--
作者：
Kobayashi, Hiroki;Uno, Takashi;Ito, Hisao
研究剂量-体积因素对接受每日2次放疗联合卡铂和紫杉醇化疗的非小细胞肺癌患者发生放射性肺炎的影响。放疗包括每日2次分割1.2戈伊，总剂量为60戈伊。每周卡铂和紫杉醇作为同步化疗。回顾性分析放射治疗参数对放射性肺炎发生的影响，37例患者中有14例发生2级或更严重（≥ G2）放射性肺炎。V5> 40%的5例患者、V10> 35%的4例患者、V13> 32%的4例患者、V20> 24%的14例患者中有9例患者、V30> 22%的11例患者中有8例患者发生了2级或更严重的放射性肺炎，而V5 <40%的32例患者中有9例患者发生了2级或更严重的放射性肺炎，V10 <35%的33例患者中有10例，V13 <32%的33例患者中有10例，V20 <24%的23例患者中有5例，V30 <22%的26例患者中有6例，P值分别为0.0045、0.015、0.015、0.015和0.008。平均肺剂量> 14戈伊的11例患者中有8例发生≥ G2放射性肺炎，而平均肺剂量<14戈伊的26例患者中有6例发生≥ G2放射性肺炎（P = 0.008）。
To examine the effects of dose-volume factors on the development of radiation pneumonitis in patients with non-small-cell lung cancer who received twice-daily radiotherapy concurrently with carboplatin and paclitaxel chemotherapy.Radiotherapy consisted of twice-daily fractionation of 1.2 Gy, to a total dose of 60 Gy. Weekly carboplatin and paclitaxel were used as a concurrent chemotherapy. Effects of radiotherapy parameters on the development of radiation pneumonitis were retrospectively analyzed.Fourteen of 37 patients developed Grade 2 or worse (>= G2) radiation pneumonitis. Grade 2 or worse radiation pneumonitis occurred in all 5 patients with V5 > 40%, all 4 patients with V10 > 35%, all 4 patients with V13 > 32%, 9 of 14 patients with V20 > 24% and 8 of 11 patients with V30 > 22%, whereas 9 of 32 patients with V5 < 40%, 10 of 33 patients with V10 < 35%, 10 of 33 patients with V13 < 32%, 5 of 23 patients with V20 < 24% and 6 of 26 patients with V30 < 22%, with respective P values of 0.0045, 0.015, 0.015, 0.015 and 0.008. Eight of 11 patients with a mean lung dose of > 14 Gy developed >= G2 radiation pneumonitis in contrast to 6 of 26 patients with a mean lung dose of < 14 Gy (P = 0.008).Several cut-off values in the V(dose) and the mean lung dose differentiating probabilities of developing >= G2 radiation pneumonitis were identified in this combination therapy.