SPREAD OF SCRAPIE TO SHEEP AND GOATS BY ORAL DOSING WITH FETAL MEMBRANES FROM SCRAPIE-AFFECTED SHEEP
SPREAD OF SCRAPIE TO SHEEP AND GOATS BY ORAL DOSING WITH FETAL MEMBRANES FROM SCRAPIE-AFFECTED SHEEP
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DOI：
10.1136/vr.90.17.465
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发表时间：
1972-01-01
影响因子：
2.2
通讯作者：
JEBBETT, JN
中科院分区：
文献类型：
--
作者：
PATTISON, IH;WATSON, WA;JEBBETT, JN
在妊娠后期获得了6只患痒病的斯韦代尔母羊的胎膜。每只母羊的膜分别用于4只绵羊和6只山羊的实验接种。两只绵羊和三只山羊脑内注射了由一小部分膜制备的接种剂；另外两只绵羊和三只山羊被喂食了剩余的悬浮液，重量从165克到650克不等。迄今为止（实验开始30个月后），4只供体母羊的胎膜已被证明具有传染性。口服接种的5只绵羊和3只山羊发生了痒病，脑内接种的4只绵羊和1只山羊发生了痒病。由于绵羊在产羔期会吃其他绵羊排出的胎膜，并且由于痒病的传播因子对不利的物理和化学处理具有很强的抵抗力，并且在高稀释条件下具有活性，因此我们认为痒病可能通过摄入受感染绵羊的胎膜或被这些胎膜污染的物质而传播。
Foetal membranes were obtained in late pregnancy from six scrapie-affected Swaledale ewes. The membranes from each ewe were used for the experimental inoculation of four sheep and six goats. Two sheep and three goats were injected intracerebrally with an inoculum prepared from a small portion of the membranes; two other sheep and three other goats were fed a suspension of the remainder which ranged in weight from 165 to 650 g. To date (30 months after beginning the experiment) foetal membranes from four donor ewes have proved infective. Scrapie has occurred in five sheep and three goats dosed orally, and in four sheep and one goat inoculated intracerebrally. Because sheep will eat foetal membranes voided by other sheep at lambing times, and because the transmissible agent of scrapie is very resistant to adverse physical and chemical treatments and is active in high dilution, it is suggested that scrapie may be spread by the ingestion of foetal membranes from affected sheep, or material contaminated by such membranes.