Insulin in the brain increases gain of baroreflex control of heart rate and lumbar sympathetic nerve activity.
Insulin in the brain increases gain of baroreflex control of heart rate and lumbar sympathetic nerve activity.
复制标题
大脑中的胰岛素会增加压力反射对心率和腰交感神经活动的控制。
DOI：
10.1161/hypertensionaha.107.102608
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发表时间：
2008
期刊：
影响因子：
--
通讯作者：
Brooks,VirginiaL
中科院分区：
文献类型：
--
作者：
Pricher,MollieP;Freeman,KorrinaL;Brooks,VirginiaL
慢性中枢胰岛素给药增加了心率的压力反射控制的增益，但交感神经系统的压力反射控制是否受到类似的影响尚不清楚。脑胰岛素影响压力感受器反射的部位和机制也不清楚。因此，本研究测试的假设，急性输注胰岛素到脑室的麻醉大鼠增加增益的压力反射控制的心率和腰交感神经活动，这种行动是性别特异性的。此外，为了确定脑内介导这些效应的位置，将胰岛素注入侧脑室或第四脑室。侧脑室胰岛素输注增加了60 ~ 90分钟内压力反射对心率的控制增益（2.1±0.3 ~ 4.0±0.6 bpm/mm Hg;P<0.05）和交感神经活性（2.3±0.3%~ 4.8±1.1% control/mm Hg;P<0.05）;然而，心率增益的增加在男性和女性中相似。压力反射对心率的最大控制（395±10至452±13 bpm;P<0.05）和交感神经活动（156±13%至253±22%对照;P<0.05）也有所增加。相反，第四心室胰岛素输注未能改变压力感受器反射功能。总之，脑胰岛素的增加在前脑中起急性作用，以增强心率和腰交感神经活动的压力反射控制的增益。
Chronic central administration of insulin increases the gain of baroreflex control of heart rate, but whether baroreflex control of the sympathetic nervous system is similarly affected is unknown. The sites and mechanisms by which brain insulin influences the baroreflex are also unclear. Therefore, the present study tested the hypothesis that acute infusion of insulin into the brain ventricles of urethane-anesthetized rats increases gain of baroreflex control of heart rate and lumbar sympathetic nerve activity and that this action is gender specific. Furthermore, to identify the location within the brain that mediates these effects, insulin was infused into either the lateral ventricle or the fourth ventricle. Lateral ventricular insulin infusion increased the gain of baroreflex control of heart rate (2.1±0.3 to 4.0±0.6 bpm/mm Hg;P<0.05) and sympathetic activity (2.3±0.3% to 4.8±1.1% control/mm Hg;P<0.05) within 60 to 90 minutes; however, the increase in heart rate gain was similar in males and females. Increases in the maximum of baroreflex control of heart rate (395±10 to 452±13 bpm;P<0.05) and of sympathetic activity (156±13% to 253±22% control;P<0.05) were also observed. In contrast, fourth ventricular insulin infusion failed to alter baroreflex function. In conclusion, increases in brain insulin act acutely in the forebrain to enhance gain of baroreflex control of heart rate and lumbar sympathetic nerve activity.