Analysis of risk factors for abdominal aortic aneurysm in a cohort of more than 3 million individuals
Analysis of risk factors for abdominal aortic aneurysm in a cohort of more than 3 million individuals
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DOI：
10.1016/j.jvs.2010.05.090
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发表时间：
2010-09-01
影响因子：
4.3
通讯作者：
Greco, Giampaolo
中科院分区：
文献类型：
--
作者：
Kent, K. Craig;Zwolak, Robert M.;Greco, Giampaolo
背景腹主动脉瘤（AAA）疾病是一种潜伏性疾病，破裂后死亡的可能性为85%。超声筛查可以降低死亡率，但它的使用是提倡只为有限的子集的人口risk.Methods：我们使用的数据从一个回顾性队列的310万例患者谁完成了医疗和生活方式问卷，并进行了评估，超声成像的存在下AAA的生命线筛选在2003年至2008年。与AAA相关的危险因素，确定使用多变量Logistic回归analysis.Results：我们观察到一个积极的关联，增加吸烟和吸烟和戒烟的负相关。超重与风险增加有关，而运动和坚果，蔬菜和水果的消费与风险降低有关。黑人、西班牙裔和亚洲人患AAA的风险低于白人和美洲原住民。众所周知的危险因素，包括男性性别，年龄，家族史和心血管疾病。创建了一个预测评分系统，该系统比当前标准更有效地识别动脉瘤，包括女性，非吸烟者和老年人
Background. Abdominal aortic aneurysm (AAA) disease is an insidious condition with an 85% chance of death after rupture. Ultrasound screening can reduce mortality, but its use is advocated only for a limited subset of the population at risk.Methods: We used data from a retrospective cohort of 3.1 million patients who completed a medical and lifestyle questionnaire and were evaluated by ultrasound imaging for the presence of AAA by Life Line Screening in 2003 to 2008. Risk factors associated with AAA were identified using multivariable logistic regression analysis.Results: We observed a positive association with increasing years of smoking and cigarettes smoked and a negative association with smoking cessation. Excess weight was associated with increased risk, whereas exercise and consumption of nuts, vegetables, and fruits were associated with reduced risk. Blacks, Hispanics, and Asians had lower risk of AAA than whites and Native Americans. Well-known risk factors were reaffirmed, including male gender, age, family history, and cardiovascular disease. A predictive scoring system was created that identifies aneurysms more efficiently than current criteria and includes women, nonsmokers, and individuals aged