REGIONAL PATTERN OF DEGENERATION IN ALZHEIMERS-DISEASE - NEURONAL LOSS AND HISTOPATHOLOGICAL GRADING
REGIONAL PATTERN OF DEGENERATION IN ALZHEIMERS-DISEASE - NEURONAL LOSS AND HISTOPATHOLOGICAL GRADING
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DOI：
10.1111/j.1365-2559.1981.tb01818.x
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发表时间：
1981-01-01
期刊：
影响因子：
6.4
通讯作者：
ENGLUND, E
中科院分区：
文献类型：
--
作者：
BRUN, A;ENGLUND, E
对阿尔采末病的人类皮质变性的各种结构成分进行了定义和分级。退化过程的严重程度映射在不同的皮质区，其中神经元数量和皮质宽度也进行了测量，并与对照组进行比较。与一般认为的颞叶内侧和额叶皮质的退行性变是均匀扩散的相反，我们发现了一种一致的、更复杂的、具有明显区域差异的退行性变，除基底内侧颞叶边缘区外，还包括后扣带回和上级顶叶上小叶，顶下小叶和颞下回的变化不太明显。皮质的感觉运动区、距状区和前扣带区直到非常晚期才明显幸免。这种区域性变化的严重程度的退化是由区域性变化的神经元数量和皮质宽度减少，并同意与临床参数密切相关的区域模式，包括症状模式和区域脑血流改变。
The various structural components of human cortical degeneration of Alzheimer''s disease were defined and graded. The severity of the degenerative process was mapped in different cortical areas where neuronal numbers and cortical width were also measured and compared with controls. Contrary to the general opinion that the degenerative process is rather uniformly diffuse, though accentuated in the medial temporal and frontal cortex, a consistent and more elaborate pattern with clearcut regional differences was found. The degeneration involved, besides basal medial temporal limbic areas, the posterior cingulate gyrus and superior parietal lobule particularly, with somewhat less marked changes in the inferior parietal lobule and inferior temporal gyri. The sensorimotor, calcarine and anterior cingulate areas of the cortex were notably spared until very late stages. This regionally variable severity of the degeneration was paralleled by a regionally varying reduction in neuronal numbers and cortical width, and agrees with a regional pattern which closely correlates with clinical parameters, including symptom pattern and regional cerebral blood flow alterations.