Longitudinal pattern of regional brain volume change differentiates normal aging from MCI
Longitudinal pattern of regional brain volume change differentiates normal aging from MCI
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DOI：
10.1212/wnl.0b013e3181a82634
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发表时间：
2009-06-02
期刊：
影响因子：
9.9
通讯作者：
Resnick, S. M.
中科院分区：
文献类型：
--
作者：
Driscoll, I.;Davatzikos, C.;Resnick, S. M.
背景资料：神经影像学测量有可能作为疾病的替代标志物，通过识别临床症状之前发生的一致特征。尽管进行了大量的研究，特别是与临床损伤的过渡有关的研究，但临床正常老年人大脑变化的区域模式尚未建立。我们预测，与阿尔茨海默病的早期病理变化的地区，将显示加速体积损失的轻度认知功能障碍（MCI）相比，正常老化。方法：通过巴尔的摩纵向研究老化，我们前瞻性地评估了138个非痴呆症的个人（年龄64-86岁），每年长达10年。在研究过程中，18名参与者被诊断患有MCI。混合效应回归用于比较临床正常个体与MCI个体的局部脑体积轨迹，基于总共1，017个观察结果。观察到心室CSF（vCSF）、额叶灰质、上级、中间和内侧额叶以及上级顶叶区域随着年龄的增长而加速变化（p
Background: Neuroimaging measures have potential as surrogate markers of disease through identification of consistent features that occur prior to clinical symptoms. Despite numerous investigations, especially in relation to the transition to clinical impairment, the regional pattern of brain changes in clinically normal older adults has not been established. We predict that the regions that show early pathologic changes in association with Alzheimer disease will show accelerated volume loss in mild cognitive impairment (MCI) compared to normal aging.Methods: Through the Baltimore Longitudinal Study of Aging, we prospectively evaluated 138 nondemented individuals (age 64-86 years) annually for up to 10 consecutive years. Eighteen participants were diagnosed with MCI over the course of the study. Mixed-effects regression was used to compare regional brain volume trajectories of clinically normal individuals to those with MCI based on a total of 1,017 observations.Results: All investigated volumes declined with normal aging (p < 0.05). Accelerated change with age was observed for ventricular CSF (vCSF), frontal gray matter, superior, middle, and medial frontal, and superior parietal regions (p