Sudden cardiac arrest in patients with schizophrenia: A population-based study of resuscitation outcomes and pre-existing cardiovascular disease.
Sudden cardiac arrest in patients with schizophrenia: A population-based study of resuscitation outcomes and pre-existing cardiovascular disease.
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DOI：
10.1016/j.ijcha.2022.101027
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发表时间：
2022-06
影响因子：
2.9
通讯作者：
Reinier, Kyndaron
中科院分区：
文献类型：
--
作者：
Edwards, Gabriel G.;Uy-Evanado, Audrey;Stecker, Eric C.;Salvucci, Angelo;Jui, Jonathan;Chugh, Sumeet S.;Reinier, Kyndaron
关键词：
精神分裂症患者心血管疾病负担较高，心脏骤停 (SCA) 发生率较高，但关于该人群 SCA 生存率的已发表数据很少。作者比较了患有和不患有精神分裂症的个体在 SCA 后的心血管疾病负担和复苏结果。病例对照分析源自大型社区 SCA 的前瞻性社区研究。作者将病例定义为在 SCA 之前有精神分裂症病史，将对照定义为没有精神分裂症病史的 SCA 个体。将患有精神分裂症的 SCA 病例与 1:5 年龄和性别频率匹配的不患有精神分裂症的 SCA 病例样本进行比较。 103 例 SCA 精神分裂症病例与 515 例非精神分裂症病例尝试复苏的可能性相同（75% 对比 80%；p = 0.24），并且 911 呼叫平均响应时间更短（5.8 分钟对比 6.9 分钟，p < 0.001）。然而，他们出现可电击心律的可能性明显较低（心室颤动/无脉性室性心动过速 16% vs. 43%，p < 0.001），并且存活到出院的可能性也较小（3% vs. 14%，p = 0.008）。患有和不患有精神分裂症的患者在逮捕前的心血管疾病负担相似。尽管复苏特征和心血管疾病负担相当，但精神分裂症患者的 SCA 存活率显着较低。之前对这种现象的研究很少，需要进一步研究以确定可能提高生存率的因素。
Individuals with schizophrenia carry a high burden of cardiovascular disease and elevated rates of sudden cardiac arrest (SCA), but little published data is available regarding survival from SCA in this population. The authors compared cardiovascular disease burden and resuscitation outcomes following SCA in individuals with and without schizophrenia. Case-control analysis drawn from a prospective community-based study of SCA in a large community. The authors defined cases as having a pre-SCA history of schizophrenia, and controls as individuals with SCA without a history of schizophrenia. SCA cases with schizophrenia were compared to a 1:5 age- and sex-frequency-matched sample of SCA cases without schizophrenia. The 103 SCA schizophrenia cases were as likely as the 515 cases without schizophrenia to have resuscitation attempted (75% vs. 80%; p = 0.24) and had a shorter 911 call mean response time (5.8 min vs. 6.9 min, p < 0.001). However, they were significantly less likely to present with a shockable rhythm (ventricular fibrillation/pulseless ventricular tachycardia 16% vs. 43%, p < 0.001), and less likely to survive to hospital discharge (3% vs. 14%, p = 0.008). Pre-arrest cardiovascular disease burden was similar in patients with and without schizophrenia. Despite comparable resuscitation characteristics and cardiovascular disease burden, patients with schizophrenia had significantly lower rates of SCA survival. The paucity of previous research into this phenomenon warrants further investigation to identify factors that may improve survival.
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影响因子：
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作者：
Burashnikov, Elena;Pfeiffer, Ryan;Barajas-Martinez, Hector;Delpon, Eva;Hu, Dan;Desai, Mayurika;Borggrefe, Martin;Haeissaguerre, Michel;Kanter, Ronald;Pollevick, Guido D.;Guerchicoff, Alejandra;Laino, Ruben;Marieb, Mark;Nademanee, Koonlawee;Nam, Gi-Byoung;Robles, Roberto;Schimpf, Rainer;Stapleton, Dwight D.;Viskin, Sami;Winters, Stephen;Wolpert, Christian;Zimmern, Samuel;Veltmann, Christian;Antzelevitch, Charles
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影响因子：
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作者：
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通讯作者：
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影响因子：
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作者：
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通讯作者：
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3.4
作者：
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