R-Type Lectins
R-Type Lectins
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DOI：
10.1101/glycobiology.3e.031
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发表时间：
2009
期刊：
影响因子：
--
通讯作者：
R. Cummings;M. Etzler
中科院分区：
文献类型：
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作者：
R. Cummings;M. Etzler
R型凝集素是一个蛋白质超家族的成员，该家族含有一个结构上与蓖麻毒素相似的碳水化合物识别结构域（CRD）。蓖麻毒素被认为是第一个被发现的凝集素，因此它是这一类凝集素的原型。R型凝集素存在于植物、动物和细菌中，并且在某些情况下凝集素结构域与作为有效毒素的单独亚基相关。本章讨论了这组蛋白质的结构-功能关系。
The R-type lectins are members of a superfamily of proteins that contain a carbohydrate-recognition domain (CRD) that is structurally similar to the one in ricin. Ricin is considered the first lectin to be discovered, and it is thus the prototypical lectin in this category. R-type lectins are present in plants, animals, and bacteria, and the lectin domain in some cases is associated with a separate subunit that is a potent toxin. The structure–function relationships of this group of proteins are discussed in this chapter.