Decreased nitric oxide production in primary open-angle glaucoma
Decreased nitric oxide production in primary open-angle glaucoma
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DOI：
10.1177/112067210201200109
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发表时间：
2002-01-01
影响因子：
1.7
通讯作者：
Er, H
中科院分区：
文献类型：
--
作者：
Doganay, S;Evereklioglu, C;Er, H
目的.眼内压升高是原发性开角型青光眼视神经损害的主要危险因素。小梁网作为一个阀门，在水流出和放松与一氧化氮（NO）激动剂。由于NO是由体内其他部位的内皮细胞和平滑肌合成的，因此本研究调查了POAG患者与白内障患者相比，房水中的NO水平。在择期手术期间，通过穿刺术从16名POAG患者（9名男性和7名女性;平均年龄69.0 ± 3.4岁）和14名年龄和性别匹配的白内障对照组（8名男性和6名女性;平均年龄66.7 ± 4.1岁）中采集房水样本。作为NO的指示剂，通过Greiss反应测量水溶液中的总亚硝酸盐水平（NO的最终产物）。采用Mann-Whitney U检验进行统计学分析，P
PURPOSE. Raised intraocular pressure (IOP) is the major risk factor responsible for optic nerve damage in primary open-angle glaucoma (POAG). The trabecular meshwork acts as a valve in aqueous outflow and relaxes with nitric oxide (NO) agonists. Since NO is synthesized by endothelium and smooth muscle elsewhere in the body, this study investigated the NO levels in the aqueous humor of patients with POAG compared with cataract patients.MATERIALS AND METHODS. Aqueous humor samples were taken by paracentesis from 16 consecutive patients with POAG (9 male and 7 female; mean age 69.0 +/- 3.4 yrs) and 14 age and sex-matched controls with cataract (8 male and 6 female; mean age 66.7 +/- 4.1 yrs) during elective surgery. As an indicator for NO, aqueous total nitrite levels (end - product of NO) were measured by Greiss reaction. The Mann-Whitney U test was used for statistical analysis and P