Practical synthesis of 2-deoxy sugars via metal free deiodination reactions
Practical synthesis of 2-deoxy sugars via metal free deiodination reactions
复制标题
通过无金属脱碘反应实际合成2-脱氧糖
DOI：
10.1080/07328303.2021.2015365
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发表时间：
2022-01-13
影响因子：
1
通讯作者：
Wan，Qian
中科院分区：
文献类型：
--
作者：
Yao，Wang;Wang，Hao;Wan，Qian
摘要2-脱氧糖苷是许多生物活性天然产物和药物分子中的重要结构单元，其中C-2羟基被氢原子取代。本文报道了以环己烷和乙酸乙酯为共溶剂的一种改进的过氧化二月桂酰基自由基脱碘反应。这是一种环境友好的方案，在温和的条件下平稳运行，并允许以高达98%的产率有效地制备一系列2-脱氧-糖苷。图形摘要
Abstract 2-Deoxy-glycosides, in which the C-2 hydroxyl group is replaced with a hydrogen atom, are important motifs in numerous bioactive natural products and pharmaceutical molecules. Herein, an improved dilauroyl peroxide-mediated radical deiodination reaction by using cyclohexane and ethyl acetate as co-solvent is reported. This is an environmentally benign protocol, which operates smoothly under mild conditions and allows efficient preparation of a series of 2-deoxy-glycosides in up to 98% yields. Graphical Abstract