Association of sleep duration with type 2 diabetes and impaired glucose tolerance
Association of sleep duration with type 2 diabetes and impaired glucose tolerance
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DOI：
10.1007/s00125-007-0786-x
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发表时间：
2007-11-01
期刊：
影响因子：
8.2
通讯作者：
Tremblay, A.
中科院分区：
文献类型：
--
作者：
Chaput, J.-P.;Despres, J.-P.;Tremblay, A.
目的/假设-本研究的目的是评估睡眠持续时间和2型糖尿病或糖耐量受损（IGT）之间的关系。方法人体测量和自我报告的睡眠持续时间进行了测定，年龄在21-64岁的魁北克家庭研究的323名男性和417名女性的横断面样本。比较短睡眠时间（5-6 h）、“正常”睡眠时间（7-8 h）和长睡眠时间（9-10 h）组的葡萄糖稳态指标。2型糖尿病/IGT的校正比值比为1.58（1.13-2.31）对于睡眠时间为9-10小时的受试者和2.09（1.34-2.98）对于睡眠时间为5-6小时的受试者，在调整潜在的混杂变量后。短睡眠者和长睡眠者的总胰岛素AUC显著更高（p < 0.05），而总葡萄糖AUC在两种性别的三个睡眠者组之间没有差异。空腹血糖浓度下的平均血糖面积明显高于空腹血糖浓度下的平均血糖面积。（p < 0.01）和长睡眠者（p < 0.05）与“正常”睡眠者相比，简而言之，（p < 0.05）。结论/解释本研究提供的证据表明，睡眠时间短和睡眠时间长与2型糖尿病相关。成人IGT，即使调整了几个混杂因素。这些结果还表明，在短睡眠者中观察到OGTT结束时较低的葡萄糖浓度。根据食欲控制的葡萄糖抑制理论，这代表了一种可以触发饥饿和自发食物摄入的刺激，这至少可以部分解释短睡眠者表现出的更大超重风险，如以前的研究所示。
Aims/hypothesis The aim of this study was to assess the relationship between sleep duration and type 2 diabetes or impaired glucose tolerance (IGT).Methods Anthropometric measurements and self-reported sleep duration were determined in a cross-sectional sample of 323 men and 417 women aged 21-64 years from the Quebec Family Study. Glucose homeostasis indicators were compared between short (5-6 h), 'normal' (7-8 h) and long (9-10 h) sleeper groups.Results Using adults with 7-8 h of sleep as a reference, the adjusted odds ratio for type 2 diabetes/IGT was 1.58 (1.13-2.31) for those with 9-10 h of sleep and 2.09 (1.34-2.98) for those with 5-6 h of sleep, after adjustment for potential confounding variables. The short and long sleepers presented significantly higher total insulin AUC (p < 0.05), whereas total glucose AUC was not different between the three sleeper groups in both sexes. The mean glucose area below fasting glucose concentrations was significantly higher in short (p < 0.01) and long sleepers (p < 0.05) compared with 'normal' sleepers, and significantly higher in short (p < 0.05) compared with long sleepers in both sexes.Conclusions/interpretation The present study provides evidence that short- and long-duration sleep times are associated with type 2 diabetes/IGT in adults, even after adjustment for several confounders. These results also showed that the lower glucose concentrations at the end of the OGTT were observed in short sleepers. According to the glucostatic theory of appetite control, this represents a stimulus that can trigger episodes of hunger and spontaneous food intake, which may explain at least in part the greater risk of overweight displayed by short sleepers, as shown in previous studies.