Morphology tailoring and temperature sensitivity control of waist cross-linked micelles and evaluation of their application as intelligent drug carriers
Morphology tailoring and temperature sensitivity control of waist cross-linked micelles and evaluation of their application as intelligent drug carriers
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DOI：
10.1039/c0jm02023k
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发表时间：
2010-11
影响因子：
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通讯作者：
C. Yuan;Yiting Xu;Y-H Liao;Sujuan Lin;N. He;L. Dai
中科院分区：
文献类型：
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作者：
C. Yuan;Yiting Xu;Y-H Liao;Sujuan Lin;N. He;L. Dai
通过两亲性低聚物十八烷基聚乙二醇丁烯二酸酯（O-B-EGs）的自组装引导自由基聚合，制备了一种新型腰部交联胶束（WCM）作为智能药物载体。通过改变O-B-EG反应液的浓度，得到了单层、复合和囊泡状的WCM。这些WCM显示出可控的温度响应特性。DLS和UV-vis分析表明，随着PEG链分子量的增加，WCMs粒径突变的临界温度明显增加。通过温度的微小变化也可以实现WCMs中芘释放的直接切换。芘在WCM临界温度附近的温度下迅速释放，但温度的进一步升高会关闭芘的释放。更重要的是，这些WCM具有可逆和快速的芘释放-吸收行为。这些优异的性能使WCM在药物包封和控制释放方面具有巨大的潜力
A novel type of waist cross-linked micelle (WCM) was developed as an intelligent drug carrier via the self-assembly guiding free radical polymerization of an amphiphilic oligomer: octadecyl, polyethylene glycol butenedioates (O–B–EGs). By changing the concentration of O–B–EG reaction solution, WCMs with monolayer, compound and vesicle-like morphologies were obtained. These WCMs showed controllable temperature responsive properties. DLS and UV-vis analyses indicate that the critical temperatures at which WCMs show an abrupt change in particle size evidently increases with the increase in the molecular weight of the PEG chains. Direct switching of the release of pyrene in WCMs is also realized by a slight change of temperature. Pyrene is released rapidly at the temperatures around the critical temperature of the WCMs, but a further increase in temperature shuts down the release of pyrene. More importantly, these WCMs exhibit reversible and rapid pyrene releasing-absorbing behavior. We suggest that these excellent properties endow WCMs with great potential in drug encapsulation and controlled release