METABOLISM OF TRIGLYCERIDE-RICH LIPOPROTEINS DURING ALIMENTARY LIPEMIA
METABOLISM OF TRIGLYCERIDE-RICH LIPOPROTEINS DURING ALIMENTARY LIPEMIA
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DOI：
10.1172/jci116293
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发表时间：
1993-03-01
影响因子：
15.9
通讯作者：
HAMSTEN, A
中科院分区：
文献类型：
--
作者：
KARPE, F;STEINER, G;HAMSTEN, A
研究了健康对照和冠状动脉疾病正常（NTG）和高甘油三酯血症（HTG）患者口服脂肪负荷摄入后乳糜微粒残留物和VLDL的代谢。特异性测定载脂蛋白B-48和B-100可以分离两种脂蛋白各自的贡献。对照组和NTG患者餐后血浆小（Sf 20-60）和大（Sf 60-400）乳糜微粒残留物水平升高。相比之下，HTG患者只有大的乳糜微粒残留物增加。在所有组中，大VLDL都随着口服脂肪负荷的增加而增加，而小VLDL在对照组和NTG患者中没有变化，或者在HTG患者组中减少。C型载脂蛋白的全血浆浓度基本上不受口服脂肪负荷的影响，而大甘油三酯富脂蛋白的含量与对照组和NTG患者的载脂蛋白B升高相似。HTG组大甘油三酯富脂蛋白中载脂蛋白B的增加更为显著，但不伴有C载脂蛋白的增加。这些发现表明，乳糜微粒通过脂蛋白脂肪酶与VLDL竞争去除甘油三酯，并且在高甘油三酯血症中富含甘油三酯的脂蛋白的餐后代谢严重缺陷。
The metabolism of chylomicron remnants and VLDL was studied in healthy controls and normo- (NTG) and hypertriglyceridemic (HTG) patients with coronary artery disease after intake of an oral fat load. Specific determination of apo B-48 and B-100 enabled separation of the respective contribution of the two lipoprotein species. The postprandial plasma levels of small (Sf 20-60) and large (Sf 60-400) chylomicron remnants increased in controls and NTG patients. In contrast, only large chylomicron remnants increased in the HTG patients. An increase of large VLDL was seen in response to the oral fat load in all groups, whereas small VLDL were either unchanged in the controls and the NTG patients, or decreased in the HTG patient group. The whole plasma concentration of C apolipoproteins was essentially uninfluenced by the oral fat load, whereas the content in large triglyceride-rich lipoproteins paralleled the apo B elevations in controls and NTG patients. An even more prominent increase of apo B in large triglyceride-rich lipoproteins in the HTG group was not accompanied by an increase of C apolipoproteins. These findings indicate that chylomicrons compete with VLDL for removal of triglycerides by lipoprotein lipase and that the postprandial metabolism of triglyceride-rich lipoproteins is severely defective in hypertriglyceridemia.